Stachydrine, a potential drug for the treatment of cardiovascular system and central nervous system diseases

Cardiovascular disease (CVD) is the leading cause of death globally and poses at significant challenge in terms of effective medical treatment. Leonurus japonicus Houtt, a traditional Chinese herb, is widely used in China for the treatment of obstetrical and gynecological disorders, including menstrual disorders, dysmenorrhea, amenorrhea, blood stasis, postpartum bleeding, and blood-related diseases such as CVD. Stachydrine, the main alkaloid component of Leonurus, has been shown to exhibit a wide range of biological activities including antiinflammatory, antioxidant, anti-coagulant, anti-apoptotic, vasodilator, angiogenic promoter. Additionally, it has been demonstrated to have unique advantages in the prevention and treatment of CVD through regulation of various disease-related signaling pathways and molecular targets. In this comprehensive review, we examine the latest pharmacological effects and molecular mechanisms of Stachydrine in treating cardiovascular and cerebrovascular diseases. Our aim is to solid scientific basis for the development of new CVD drug formulations.

Automated summary

Cardiovascular disease (CVD) is a leading cause of death worldwide and effective medical treatment is still a challenge. Leonurus japonicus Houtt, a traditional Chinese herb, has been widely used in China for the treatment of obstetrical and gynecological disorders as well as CVD. The main alkaloid component, stachydrine, has shown various biological activities and unique advantages in the prevention and treatment of CVD. This review aims to explore the pharmacological effects and molecular mechanisms of stachydrine in treating cardiovascular and cerebrovascular diseases, providing a scientific basis for the development of new CVD drug formulations.