Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 162, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2023.114631
Keywords
ScRNA-seq; Skeletal muscle; Cellular heterogeneity; Pseudotime patterns; Cell-cell communication
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Skeletal muscle, derived from paraxial mesodermal somites, is the most extensive tissue in mammals and undergoes hyperplasia and hypertrophy to form functional muscle fibers. Characterizing the cellular heterogeneity and transcriptional signatures of skeletal muscle is crucial for understanding its development. Single-cell sequencing technology has enabled the exploration of skeletal muscle cell types and molecular events, providing insights into skeletal muscle pathophysiology.
Skeletal muscle is the most extensive tissue in mammals, and they perform several functions; it is derived from paraxial mesodermal somites and undergoes hyperplasia and hypertrophy to form multinucleated, contractile, and functional muscle fibers. Skeletal muscle is a complex heterogeneous tissue composed of various cell types that establish communication strategies to exchange biological information; therefore, characterizing the cellular heterogeneity and transcriptional signatures of skeletal muscle is central to understanding its ontogeny's details. Studies of skeletal myogenesis have focused primarily on myogenic cells' proliferation, differentiation, migration, and fusion and ignored the intricate network of cells with specific biological functions. The rapid development of single-cell sequencing technology has recently enabled the exploration of skeletal muscle cell types and molecular events during development. This review summarizes the progress in single-cell RNA sequencing and its applications in skeletal myogenesis, which will provide insights into skeletal muscle pathophysiology.
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