4.5 Article

Kappa-carrageenan based hybrid hydrogel for soft tissue engineering applications

Related references

Note: Only part of the references are listed.
Article Engineering, Biomedical

Extracellular vesicle-loaded hydrogels for tissue repair and regeneration

Yikun Ju et al.

Summary: Extracellular vesicles (EVs) are secreted by cells and have significant potential in regenerative medicine. Mesenchymal stem cells can secrete EVs that promote tissue repair and regeneration. However, EVs are rapidly cleared by the circulatory system, so using hydrogels to carry and slow the release of EVs can be an effective approach.

MATERIALS TODAY BIO (2023)

Article Biochemistry & Molecular Biology

Dentin extracellular matrix loaded bioactive glass/GelMA support rapid bone mineralization for potential pulp regeneration

Aida Sadeghian et al.

Summary: The study developed a novel hydrogel for dental pulp regeneration, which consists of dentin extracellular matrix (dECM) loaded with gelatin methacrylate (GelMA) and bioactive glass (BG). The researchers investigated the influence of dECM content on the hydrogel's characteristics and biological responses. The results showed that increasing dECM content improved the compressive strength, bioactivity, and biocompatibility of the hydrogel, making it suitable for future clinical applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

Article Materials Science, Biomaterials

Biomimetic Biomembrane Encapsulation and Targeted Delivery of a Nitric Oxide Release Platform for Therapy of Parkinson?s Disease

Zhixin Huang et al.

Summary: In this study, the red blood cell membrane (RBCM) was modified on the surface of upconversion nanoparticles (UCNPs) to effectively target the brain, overcoming the challenges posed by the blood-brain barrier and the inflammatory environment in Parkinson's disease (PD) treatment. This strategy demonstrated a light-responsive anti-inflammatory effect by decreasing proinflammatory factors and promoting the release of nitric oxide in the brain, effectively mitigating neuronal inflammatory damage in PD.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2023)

Article Pharmacology & Pharmacy

3D-Printing of Silk Nanofibrils Reinforced Alginate for Soft Tissue Engineering

Zahra Mohammadpour et al.

Summary: The main challenge in extrusion 3D bioprinting is the development of bioinks with desired properties for creating complex and patient-specific scaffolds. This study focuses on non-synthetic bioinks based on alginate and silk nanofibrils (SNF) and their optimization for soft tissue engineering. The addition of SNF improved the mechanical and biological performance of the bioink, with 2 wt.% SNF showing the best results. Overall, this study highlights the favorable properties of the Alg-2SNF bioink for extrusion-based bioprinting.

PHARMACEUTICS (2023)

Article Engineering, Biomedical

Colorimetric pH-responsive and hemostatic hydrogel-based bioadhesives containing functionalized silver nanoparticles

Elham Khadem et al.

Summary: We developed a dual-cross-linked pH-responsive hydrogel based on CAO containing Ag NPs functionalized with ATR. The hydrogel showed improved adhesive and compression strength, as well as pH-sensitivity and antibacterial properties. It also exhibited hemostatic abilities and cytocompatibility, making it a promising candidate for smart wound bioadhesives.

MATERIALS TODAY BIO (2023)

Article Chemistry, Physical

Osteoconductive visible light-crosslinkable nanocomposite for hard tissue engineering

Aida Sadeghian et al.

Summary: A novel nanocomposite hydrogel was designed with osteoconductivity and high strength, reinforced with bioactive glass to enhance mechanical properties and bioactivity, significantly promoting cell attachment, proliferation, and alkaline phosphatase activity.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2022)

Article Pharmacology & Pharmacy

Exosome-loaded hydrogels: A new cell-free therapeutic approach for skin regeneration

Banafsheh Safari et al.

Summary: The treatment of unhealable and chronic cutaneous wounds is a significant challenge. Regenerative medicine based on mesenchymal stem cells (MSCs) has potential in skin repair. Exosomes, nano-sized vesicles with immune-tolerant properties, can easily transfer their content to recipient cells and play a role in wound healing through activating specific signaling pathways. To ensure the effectiveness of exosomes, the design of an optimized delivery system such as hydrogels is necessary.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

Article Pharmacology & Pharmacy

Inspiring biomimetic system based on red blood cell membrane vesicles for effective curcumin loading and release

F. Safarpour et al.

Summary: This study introduces a biomimetic system based on red blood cell membrane vesicles for improved encapsulation and release of curcumin. By varying sonication time, the properties of the vesicles such as size and release behavior can be tuned. The system shows high drug encapsulation efficiency and cytocompatibility, making it promising for wound healing applications.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Review Nanoscience & Nanotechnology

Red blood cells membrane-derived nanoparticles: Applications and key challenges in their clinical translation

Sahil Malhotra et al.

Summary: Cellular membrane-derived nanoparticles, particularly from red blood cells (RBCs), have shown great potential in drug delivery systems. These nanoparticles possess stable lipid bilayer structures and can be loaded with different drug molecules. They also have the unique ability to fuse with other cell membranes, forming hybrid nanovesicles. However, industrial-scale production remains challenging.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2022)

Article Engineering, Biomedical

Novel fusion peptides deliver exosomes to modify injectable thermo-sensitive hydrogels for bone regeneration

Shiqing Ma et al.

Summary: The mechanical properties of SIS hydrogels improved with the addition of 3-(3,4-dihydroxyphenyl) propionic acid (CA), while fusion peptides were designed to enhance the positive effects of exosomes on osteogenic differentiation of BMSCs. The combination of exosomes, fusion peptides, and SIS hydrogels showed enhanced retention and stability at the defect site in treating rat skull defect models.

MATERIALS TODAY BIO (2022)

Review Engineering, Biomedical

Current knowledge of immunomodulation strategies for chronic skin wound repair

Parisa Heydari et al.

Summary: The immune system plays a critical role in orchestrating the wound healing process, and can be optimized using biomaterials, bioactive molecules, and cell delivery. Strategies for immunomodulation in chronic wound healing include investigating the interaction between the extracellular mechanism and immune cells, biomaterial-based strategies, and the release of bioactive agents and stem cell therapy.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2022)

Article Chemistry, Physical

Fabrication of bentonite reinforced dopamine grafted carboxymethyl xylan cross-linked with polyacrylamide hydrogels with adhesion properties

Xinxin Liu et al.

Summary: In this study, two-dimensional bentonite nanomaterials were used as nanofiller materials to synthesize dopamine grafted carboxymethyl xylan cross-linked with polyacrylamide nanocomposite hydrogels. The results showed that bentonite as a nanofiller could enhance the mechanical strength of the hydrogels. Furthermore, dopamine imparted the hydrogels with adhesion properties.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2022)

Article Materials Science, Multidisciplinary

Multilayer self-assembled kappa carrageenan/chitosan: Heparin coating on Mg alloys for improving blood compatibility

Atefeh Golshirazi et al.

Summary: This study aims to develop a layer-by-layer self-assembled coating to improve the corrosion resistance and hemocompatibility of AZ91 alloy. The results show that the AZ91 samples with MAO and multi-layer LbL coating exhibit significant improvements in corrosion resistance and hemocompatibility.

MATERIALS TODAY COMMUNICATIONS (2022)

Review Chemistry, Applied

Polysaccharides-based nanofibrils: From tissue engineering to biosensor applications

E. Soroush et al.

Summary: This article reviews the isolation methods and physical and chemical properties of cellulose nanofibrils (CNFs) and chitin nanofibrils (ChNFs). The potential biomedical applications of CNFs and ChNFs, including tissue engineering, wound dressing, and drug delivery, are highlighted.

CARBOHYDRATE POLYMERS (2022)

Article Chemistry, Physical

Fabrication of GO/ZnO nanocomposite incorporated patch for enhanced wound healing in streptozotocin (STZ) induced diabetic rats

D. Prema et al.

Summary: Wound healing is an important process in a healthy individual, and nanocomposite patches play a significant role in promoting the healing process. In this study, a nanocomposite of graphene oxide and zinc oxide was synthesized and used to fabricate a biodegradable patch with poly vinyl alcohol and chitosan. The patch exhibited good antibacterial activity, cell adhesion properties, and blood compatibility. It significantly enhanced wound closure in diabetic wounds without causing any toxic effects.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2022)

Article Biotechnology & Applied Microbiology

An ECM-Mimetic Hydrogel to Promote the Therapeutic Efficacy of Osteoblast-Derived Extracellular Vesicles for Bone Regeneration

Kenny Man et al.

Summary: This study developed an injectable hydrogel that mimics the extracellular matrix and controls the release of osteoblast-derived extracellular vesicles (EVs) to promote bone repair. The results showed that chitosan hydrogel enhanced compressive modulus and osteogenic differentiation, while reducing gelation times and proliferation compared to collagen gel. Furthermore, EVs released from chitosan hydrogel enhanced the proliferation, migration, and mineralisation of human bone marrow stromal cells. Importantly, EV-functionalised chitosan-collagen composites promoted extracellular matrix mineralisation.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

Article Chemistry, Applied

Nanocomposite hydrogel based on carrageenan-coated starch/cellulose nanofibers as a hemorrhage control material

Shima Tavakoli et al.

Summary: The study developed a novel Kappa carrageenan-coated Starch/cellulose nanofiber hydrogel with enhanced mechanical properties and adjustable biological performance, showing great potential for hemostatic applications.

CARBOHYDRATE POLYMERS (2021)

Article Chemistry, Physical

In-vitro evaluation of electrospun cellulose acetate nanofiber containing Graphene oxide/TiO2/Curcumin for wound healing application

J. Prakash et al.

Summary: Graphene-based dressings with biocompatibility and antimicrobial properties have shown potential in wound healing. The developed CA/GO/TiO2/curcumin nanofiber demonstrated significant antibacterial activity and improved wound healing, along with exceptional hemocompatibility and biocompatibility.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2021)

Article Polymer Science

Greener therapeutic pH-sensing wound dressing based on Curcuma Longa and cellulose hydrogel

Asmaa Ahmed Arafa et al.

Summary: The study used pH-sensitive hydrogel made from turmeric extract as a cost-effective wound dressing to accelerate wound healing in a neutral medium. It was found that the hydrogel had different release properties and color changes at different pH levels, showing potential for wound healing applications.

EUROPEAN POLYMER JOURNAL (2021)

Article Cell & Tissue Engineering

Recent Advances on Bioprinted Gelatin Methacrylate-Based Hydrogels for Tissue Repair

Negar Rajabi et al.

Summary: Bioprinting of body tissues has gained significant attention for its ability to create complex geometries and print patient-specific tissues with different cell types. The use of natural polymers, especially hydrogels, in bioinks is ideal due to their high biocompatibility and minimal inflammatory response. Gelatin methacryloyl (GelMA) hydrogel stands out as a promising material for bioinks due to its low cost, biocompatibility, and versatility for soft or hard tissues.

TISSUE ENGINEERING PART A (2021)

Article Nanoscience & Nanotechnology

Development of Inherently Antibacterial, Biodegradable, and Biologically Active Chitosan/Pseudo-Protein Hybrid Hydrogels as Biofunctional Wound Dressings

Maoli Yin et al.

Summary: The study developed a new family of hydrogel-based wound dressings with antibacterial and biological functionality, without the need for antibiotics, to accelerate wound healing. The hybrid hydrogels showed excellent antibacterial activity, biocompatibility with cells, and potential for biofunctional antibacterial wound dressing candidates.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Polymer Science

The Effects of Curcumin Nanoparticles Incorporated into Collagen-Alginate Scaffold on Wound Healing of Skin Tissue in Trauma Patients

Mohammadmahdi Mobaraki et al.

Summary: In this study, collagen/alginate scaffolds incorporated with nanocurcumin showed significant potential for wound healing of skin tissue in trauma patients. The interaction between components was evaluated using FTIR spectroscopy, demonstrating improved wound healing. The results indicated that the nanocurcumin entrapped in the scaffold led to better outcomes compared to the control group.

POLYMERS (2021)

Article Engineering, Biomedical

An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing

Bin Hu et al.

Summary: A hyaluronic acid and chitosan based hydrogel with antioxidant, anti-inflammatory, and migration-promoting effects was designed in this study. The hydrogel exhibited excellent drug release capabilities in vitro and dramatically improved diabetic wound healing by flexibly releasing curcumin and epidermal growth factor according to the phases of wound healing.

BIOACTIVE MATERIALS (2021)

Review Chemistry, Multidisciplinary

Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing

Mahshid Kharaziha et al.

Summary: The immune reaction plays a critical role in chronic wound healing, with modulation of macrophages' polarization being an appealing approach in regenerative medicine. The use of hydrogels-based constructs has been recently developed to adjust immune cell functions in various stages of wound healing. The properties of hydrogels have significant effects on immunogenic features and the wound healing process.

ADVANCED MATERIALS (2021)

Article Biochemistry & Molecular Biology

Robust and double-layer micro-patterned bioadhesive based on silk nanofibril/GelMA-alginate for stroma tissue engineering

Asal Farasatkia et al.

Summary: The developed micro-patterned double-layer film provides sustained release of ascorbic acid for corneal regeneration, with the anisotropic S/G layer guiding the orientation of corneal stroma cells. The mechanical robustness and high light transmission of the hybrid film are attributed to the micro-patterned structure. The controlled release of ascorbic acid and strong tissue adhesion make the film a promising candidate for corneal tissue engineering.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Biochemistry & Molecular Biology

Shear-thinning and self-healing nanohybrid alginate-graphene oxide hydrogel based on guest-host assembly

S. Soltani et al.

Summary: The study developed a novel nanohybrid shear-thinning hydrogel with fast gelation and variable mechanical and biological properties through self-assembly and crosslinking processes. By controlling macromere concentration and host-guest ratio, the rheological and mechanical properties of hydrogels can be modulated, affecting crosslinking density and network structure. The designed nanohybrid hydrogel exhibited excellent durability and biocompatibility based on the specified parameters.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Review Polymer Science

Recent Advances in Chemically-Modified and Hybrid Carrageenan-Based Platforms for Drug Delivery, Wound Healing, and Tissue Engineering

Hamidreza Mokhtari et al.

Summary: Recent studies have focused on the advantages of carrageenan-based hydrogels, which include biocompatibility, antioxidative, antitumor properties, amongst others. Simple ionic crosslinking can transform them into three-dimensional hydrogels. Chemical modifications can overcome limitations and form chemically crosslinked hydrogels with significant mechanical properties. Incorporating nanoparticles and polymer networks results in hybrid platforms suitable for drug delivery, tissue engineering, and wound healing applications.

POLYMERS (2021)

Article Pharmacology & Pharmacy

Wound healing with alginate/chitosan hydrogel containing hesperidin in rat model

Zohreh Bagher et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

Article Chemistry, Physical

Preparation and characterization of environmentally friendly agar/κ-carrageenan/montmorillonite nanocomposite hydrogels

Tulin Gurkan Polat et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2020)

Review Engineering, Multidisciplinary

Nanocomposite hydrogels as multifunctional systems for biomedical applications: Current state and perspectives

Fazli Wahid et al.

COMPOSITES PART B-ENGINEERING (2020)

Article Materials Science, Biomaterials

A multifunctional nanocomposite spray dressing of Kappa-carrageenan-polydopamine modified ZnO/L-glutamic acid for diabetic wounds

Shima Tavakoli et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Article Biochemistry & Molecular Biology

The potential use of curcumin-β-cyclodextrin inclusion complex/chitosan-loaded cellulose sponges for the treatment of chronic wound

Kitipong Kiti et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Article Nanoscience & Nanotechnology

Stealth Polydopamine-Based Nanoparticles with Red Blood Cell Membrane for the Chemo-Photothermal Therapy of Cancer

Haijun Wang et al.

ACS APPLIED BIO MATERIALS (2020)

Article Pharmacology & Pharmacy

Carrageenan-based physically crosslinked injectable hydrogel for wound healing and tissue repairing applications

Natalia Pettinelli et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Article Chemistry, Physical

Preparation, microstructure and function for injectable liposome-hydrogels

Shiju Xu et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2019)

Article Engineering, Biomedical

A new class of biological materials: Cell membrane-derived hydrogel scaffolds

Zhiyuan Fan et al.

BIOMATERIALS (2019)

Article Biochemistry & Molecular Biology

Effective wound dressing based on Poly (vinyl alcohol)/Dextran-aldehyde composite hydrogel

Ce Zheng et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Article Chemistry, Medicinal

A novel curcumin-loaded composite dressing facilitates wound healing due to its natural antioxidant effect

Yong Zhao et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2019)

Article Pharmacology & Pharmacy

Erythrocyte Membrane Cloaked Curcumin-Loaded Nanoparticles for Enhanced Chemotherapy

Xiaotian Xie et al.

PHARMACEUTICS (2019)

Article Biochemistry & Molecular Biology

Sprayable and injectable visible-light Kappa-carrageenan hydrogel for in-situ soft tissue engineering

Shima Tavakoli et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Article Engineering, Biomedical

Nanoengineered injectable hydrogels for wound healing application

Giriraj Lokhande et al.

ACTA BIOMATERIALIA (2018)

Article Chemistry, Multidisciplinary

Magnetic Mesoporous Silica Nanoparticles Cloaked by Red Blood Cell Membranes: Applications in Cancer Therapy

Mingjun Xuan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Article Pharmacology & Pharmacy

Development of a promising drug delivery for formononetin: Cyclodextrin-modified single-walled carbon nanotubes

Xiaohong Liu et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2018)

Review Pharmacology & Pharmacy

Biomacromolecules as carriers in drug delivery and tissue engineering

Yujie Zhang et al.

ACTA PHARMACEUTICA SINICA B (2018)

Article Biochemistry & Molecular Biology

An In Vitro Study of the Effect of Cytotoxic Triorganotin Dimethylaminophenylazobenzoate Complexes on Red Blood Cells

Hanna Pruchnik et al.

JOURNAL OF MEMBRANE BIOLOGY (2018)

Article Chemistry, Applied

Nanohybrid hydrogels of laponite: PVA-Alginate as a potential wound healing material

Nasim Golafshan et al.

CARBOHYDRATE POLYMERS (2017)

Review Pharmacology & Pharmacy

Curcumin and its topical formulations for wound healing applications

Chandana Mohanty et al.

DRUG DISCOVERY TODAY (2017)

Article Chemistry, Applied

Fabrication and study of curcumin loaded nanoparticles based on folate-chitosan for breast cancer therapy application

S. Esfandiarpour-Boroujeni et al.

CARBOHYDRATE POLYMERS (2017)

Article Chemistry, Physical

Development of curcumin loaded nanostructured lipid carrier based thermosensitive in situ gel for dermal delivery

Ping Chen et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2016)

Article Chemistry, Multidisciplinary

Injectable shear-thinning nanoengineered hydrogels for stem cell delivery

Ashish Thakur et al.

NANOSCALE (2016)

Article Materials Science, Biomaterials

Tough and fully recoverable hydrogels

Junhua Wei et al.

JOURNAL OF MATERIALS CHEMISTRY B (2015)

Article Chemistry, Medicinal

Formulation and characterization of ethylcellulose microparticles containing L-alanyl- L-glutamine peptide

Monica Villa Nova et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2014)

Article Biochemistry & Molecular Biology

Superior Mechanical Properties of Double-Network Hydrogels Reinforced by Carbon Nanotubes without Organic Modification

Weifu Dong et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Article Engineering, Biomedical

Photocrosslinkable Kappa-Carrageenan Hydrogels for Tissue Engineering Applications

Silvia M. Mihaila et al.

ADVANCED HEALTHCARE MATERIALS (2013)

Review Chemistry, Multidisciplinary

Polymeric multilayer capsules for drug delivery

Stefaan De Koker et al.

CHEMICAL SOCIETY REVIEWS (2012)

Review Chemistry, Physical

Inorganic Nanoarchitectonics for Biological Applications

Katsuhiko Ariga et al.

CHEMISTRY OF MATERIALS (2012)

Article Chemistry, Physical

Preparation and swelling properties of graphene oxide/poly(acrylic acid-co-acrylamide) super-absorbent hydrogel nanocomposites

Yiwan Huang et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2012)

Review Chemistry, Multidisciplinary

Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release

Chris Oerlemans et al.

PHARMACEUTICAL RESEARCH (2010)

Review Biochemistry & Molecular Biology

Fourier transform infrared spectroscopic analysis of protein secondary structures

Jilie Kong et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2007)