Association of non-HDL-C-to-HDL-C ratio with coronary lesions and its prognostic performance in first-onset NSTEMI

Plain language summaryAcute myocardial infarction is the leading cause of cardiovascular emergencies worldwide. A novel marker, the NON-HDL-C-to-HDL-C ratio, represents the level of insulin resistance and atherogenic capacity to some extent. We analyzed the levels of this ratio in plasma to identify patients with poor prognosis. The present study indicates that high ratio was significantly associated with severe coronary artery disease and poor cardiovascular prognosis. Aim: The study sought to investigate the association of non-high-density-lipoprotein cholesterol-to-high-density-lipoprotein cholesterol ratio (NON-HDL-C:HDL-C) with coronary lesions and major adverse cardiovascular events (MACE) in first-onset non-ST-segment elevation acute myocardial infarction. Methods: A cohort of 426 patients undergoing early invasive therapy was enrolled in the final analysis. MACE included cardiac death, nonfatal myocardial infarction, target vessel revascularization, congestive heart failure and nonfatal stroke. Results: NON-HDL-C:HDL-C revealed a powerful diagnostic performance for multiple cardiovascular risk factors (p < 0.05). NON-HDL-C:HDL-C was an independent predictor for severe coronary lesions and MACE (p < 0.05). Subgroup analysis further examined the robustness, especially in elderly, male, dyslipidemic or nondiabetic patients. Conclusion: NON-HDL-C:HDL-C is associated with coronary lesions and prognosis in non-ST-segment elevation acute myocardial infarction.

Automated summary

The NON-HDL-C-to-HDL-C ratio can indicate insulin resistance and atherosclerosis to some extent. This study found that a high ratio is significantly associated with severe coronary artery disease and poor cardiovascular prognosis.