Dual signal amplified electrochemical aptasensor based on PEI-functionalized GO and ROP for highly sensitive detection of cTnI

Article Biochemistry & Molecular Biology

An electrochemical aptasensor for highly sensitive detection of CEA based on exonuclease III and hybrid chain reaction dual signal amplification

Cui Niu et al.

Summary: A novel electrochemical aptasensor based on exonuclease III and hybrid chain reaction was proposed for CEA detection, showing excellent analytical performance and great promise in early cancer screening.

BIOELECTROCHEMISTRY (2022)

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Article Chemistry, Analytical

Highly sensitive electrochemical aptasensor for SARS-CoV-2 antigen detection based on aptamer-binding induced multiple hairpin assembly signal amplification

Jian Xue et al.

Summary: In this study, a brief electrochemical aptasensor was developed for highly sensitive detection of SARS-CoV-2 antigen. The sensor utilized an aptamer-binding induced multiple hairpin assembly strategy for signal amplification. The results showed that this sensor could be used for on-site analysis of viral diseases at ambient temperature.

TALANTA (2022)

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Article Cardiac & Cardiovascular Systems

Direct comparison of high-sensitivity cardiac troponin Tand I in the early differentiation of type 1 vs. type 2 myocardial infarction

Thomas Nestelberger et al.

Summary: The study aimed to compare the diagnostic accuracy of high-sensitivity cardiac troponin T and high-sensitivity cardiac troponin I in differentiating Types 1 and 2 myocardial infarctions. The results showed that both markers provided comparable and moderate diagnostic accuracy in distinguishing between T1MI and T2MI.

EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE (2022)

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Article Chemistry, Analytical

Electrochemical immunosensor for highly sensitive detection of cTnI via in-situ initiated ROP signal amplification strategy

Di Cheng et al.

Summary: This study developed an electrochemical immunosensor based on the ROP reaction for highly sensitive detection of cTnI, showing good linearity and low detection limit. The ROP reaction method offers easy access to raw materials and mild reaction conditions, with excellent selectivity and reliability in serum sample detection.

ANALYTICA CHIMICA ACTA (2022)

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Article Biochemistry & Molecular Biology

CRISPR/Cas12a-based electrochemical biosensor for highly sensitive detection of cTnI

Hao Chen et al.

Summary: The successful fabrication of the cTnI detection platform is of great significance for instant diagnosis of myocardial injury and related cardiovascular diseases. This electrochemical biosensor, utilizing magnetic nanoparticles, aptamer, and the Cas12a/crRNA system, demonstrates high specificity and sensitivity in detecting cTnI.

BIOELECTROCHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

Dual-signal amplified electrochemical biosensor based on eATRP and PEI for early detection of lung cancer

Yan Zhou et al.

Summary: An electrochemical biosensor was developed for highly sensitive detection of CEA, using dual signal amplification of electrically mediated atom transfer radical polymerization (eATRP) and polyethyleneimine (PEI). The biosensor showed a wide linear detection range and low limit of detection. Compared to other sensors, this biosensor used a simpler and more environmentally friendly technique and improved electron transfer rate with the use of PEI. It demonstrated superior analytical performance in clinical serums and holds great promise for early lung cancer diagnosis applications.

BIOELECTROCHEMISTRY (2022)

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Article Biophysics

A dry chemistry-based ultrasensitive electrochemiluminescence immunosensor for sample-to-answer detection of Cardiac Troponin I

Tingting Zhan et al.

Summary: A dry chemistry-based, ultrasensitive closed bipolar electrode-ECL immunosensor has been designed for rapid detection of Cardiac Troponin I (cTnI). The immunosensor showed a wide linear range, high sensitivity, and good specificity, reproducibility, and stability. Moreover, the analysis process was simple and fast, making it a promising tool for early diagnosis of acute myocardial infarction and other diseases.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Chemistry, Analytical

An ultrasensitive electrochemical sensing platform based on silver nanoparticle-anchored 3D reduced graphene oxide for rifampicin detection

Qing Zhang et al.

Summary: A simple and green method was reported to anchor silver nanoparticles onto three-dimensional reduced graphene oxide, and a reliable electrochemical sensing platform was designed for the ultrasensitive detection of rifampicin. The modified electrode exhibited effective electrical activity for the analysis of RIF. The sensor showed excellent electrochemical performance for RIF detection under experimental conditions and demonstrated great potential in practical applications.

ANALYST (2022)

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Article Chemistry, Analytical

Ultrasensitive electrochemical detection of CYFRA 21-1 via in-situ initiated ROP signal amplification strategy

Jing Lu et al.

Summary: A novel electrochemical immunosensor was developed for the sensitive detection of the important biomarker CYFRA 21-1 in non-small cell lung cancer. The sensor utilized a ring-opening polymerization (ROP) signal amplification strategy to achieve high sensitivity and selectivity, showing a bright correlation in clinical serum samples. This method has great potential for ultrasensitive quantitation of biological molecules due to its ease of operation, environmental friendliness, and low cost.

ANALYTICA CHIMICA ACTA (2021)

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Article Chemistry, Analytical

Grafting of polymers via ring-opening polymerization for electrochemical assay of alkaline phosphatase activity

Xin Zhu et al.

Summary: A novel electrochemical sensor based on signal amplification strategy through ring-opening polymerization (ROP) has been developed for the assay of alkaline phosphatase (ALP) activity. The sensor showed satisfactory linear dependence, low detection limit, and good selectivity in human serum samples, with a relative error of less than 5% compared to clinical data.

ANALYTICA CHIMICA ACTA (2021)

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Article Chemistry, Analytical

Plasmon-enhanced quantum dots electrochemiluminescence aptasensor for selective and sensitive detection of cardiac troponin I

Shimeles Addisu Kitte et al.

Summary: The research demonstrated a highly sensitive electrochemiluminescence (ECL) immunosensor using functional nanoparticles as signal amplifiers for the detection of cardiac troponin I (cTnI), showing a significant signal enhancement compared to systems without gold nanoparticles. Utilizing a sandwich-type structure, the ECL platform exhibited a low detection limit and a wide linear range for cTnI detection.

TALANTA (2021)

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Article Chemistry, Analytical

Magnetic separation and enzymatic catalysis conjugated colorimetric immunosensor for Hepatitis B surface antigen detection

Yongqin Hu et al.

Summary: The study successfully developed a colorimetric immunosensor for rapid detection of HBsAg, showing good linear relationship and low detection limit. The method demonstrated successful application in real human serum samples, highlighting its potential for rapid diagnosis and prevention of infectious diseases.

MICROCHEMICAL JOURNAL (2021)

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Article Chemistry, Analytical

Functionalized graphene oxide in situ initiated ring-opening polymerization for highly sensitive sensing of cytokeratin-19 fragment

Yanju Liu et al.

Summary: This study introduced a sensitivity-improved immunosensor using functionalized graphene oxide and ring-opening polymerization strategy, demonstrating high sensitivity and applicability for detecting non-small cell lung cancer-specific biomarkers. Satisfactory results in clinical serum samples suggest the enormous potential of this immunosensor in practical clinical application.

MICROCHIMICA ACTA (2021)

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Article Chemistry, Analytical

Polymer-functionalized carbon nanotubes prepared via ring-opening polymerization for electrochemical detection of carcinoembryonic antigen

Jinge Li et al.

Summary: A novel sandwich-type electrochemical aptasensor was constructed for CEA detection, showing a wide detection range and low detection limit. PFcGE-CNTs composites prepared by ring-opening polymerization served as a platform, significantly amplifying the electrochemical signal.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

Dual signal amplification based on polysaccharide-initiated ring-opening polymerization and click polymerization for exosomes detection

Xin Zhu et al.

Summary: In this study, a novel electrochemical sensor was developed for highly sensitive detection of exosomes secreted by lung cancer cells, utilizing polysaccharide-initiated ring-opening polymerization and click polymerization. The sensor exhibited a good linear relationship, low detection limit, as well as advantages of high specificity and anti-interference.

TALANTA (2021)

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Article Chemistry, Analytical

Magnetic nanochains-based dynamic ELISA for rapid and ultrasensitive detection of acute myocardial infarction biomarkers

Di Li et al.

Summary: A novel ELISA strategy based on dynamic pseudo-homogeneous assay using bioconjugated MNCs and AuNPs probes was successfully developed for accurate detection of AMI biomarkers. This method allows rapid and sensitive detection of a panel of AMI biomarkers within 35 minutes, showing significantly improved sensitivities compared to conventional ELISA.

ANALYTICA CHIMICA ACTA (2021)

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Review Chemistry, Analytical

Electrochemical strategies for the detection of cTnI

Zhipeng Yuan et al.

Summary: This review introduces and compares various cTnI detection methods, focusing on the main indicators and limitations of cTnI biosensors, including detection range, detection limit, specificity, repeatability, and stability. Discussion on the challenges and improvements in cTnI biosensing detection in the future is also briefly included.

ANALYST (2021)

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Article Materials Science, Multidisciplinary

Ingenious construction of an electrochemical aptasensor based on a Au@COF/GO-NH2 composite with excellent detection performance

Zhang-Ye Han et al.

Summary: This study successfully prepared a novel composite and demonstrated its application in an electrochemical aptasensor, achieving high sensitivity for the detection of ultra-trace chloramphenicol. The aptasensor showed high precision, good selectivity, and strong stability.

JOURNAL OF MATERIALS CHEMISTRY C (2021)

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Article Biophysics