4.7 Article

CCL17 drives fibroblast activation in the progression of pulmonary fibrosis by enhancing the TGF-?/Smad signaling

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program

Yi Wang et al.

Summary: Despite extensive studies, the mechanisms underlying PF remain poorly understood. This study found altered MBD2 expression in macrophages in lungs from different types of PF patients and mice with PF, and Mbd2 deficiency protected against BLM-induced PF. Mbd2 selectively influenced TGF-β1 production and M2 macrophage program through Ship promoter binding in macrophages.

SCIENCE ADVANCES (2021)

Review Immunology

The inflammatory speech of fibroblasts

Ronen Schuster et al.

Summary: Activation of fibroblasts is crucial for tissue repair and fibrosis, with novel tools revealing their heterogeneous nature within a larger population of overlapping cell types. Activated fibroblasts exhibit various functions and their understanding is vital for targeted intervention in fibroproliferative and fibrocontractive disorders.

IMMUNOLOGICAL REVIEWS (2021)

Article Cell Biology

C-C Motif Chemokine Ligand-17 as a Novel Biomarker and Regulator of Epithelial Mesenchymal Transition in Renal Fibrogenesis

Yi-Hsien Hsieh et al.

Summary: CCL17, a chemotactic cytokine produced by macrophages, is elevated in chronic kidney disease patients and negatively correlated with renal function, making it a potentially useful biomarker for predicting the development of advanced CKD. In vitro and in vivo experiments demonstrate that CCL17 promotes renal fibrosis by inducing epithelial-mesenchymal transition and ECM accumulation.

CELLS (2021)

Review Biochemistry & Molecular Biology

Fibroblasts: Origins, definitions, and functions in health and disease

Maksim Plikus et al.

Summary: Fibroblasts are diverse mesenchymal cells that play a role in tissue homeostasis and disease, producing complex extracellular matrix and creating signaling niches. They are transcriptionally and functionally heterogeneous across and within organs, encoding positional information and maintaining distinct cellular progeny. Their unique properties make them poised for tissue repair but can also drive fibrotic disorders if activated aberrantly.
Article Immunology

The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis

Shan-Shan Liu et al.

Summary: Recruitment of immune cells to the site of inflammation by CCL1 is crucial in inflammatory diseases, including pulmonary fibrosis. The study found that alveolar macrophages and CD4(+) T cells are major producers of CCL1, and targeting CCL1 expression can attenuate the pathology of PF.

IMMUNITY (2021)

Article Pharmacology & Pharmacy

TRIB3-GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target

Shanshan Liu et al.

Summary: This study reveals an intact profibrotic axis of TRIB3-GSK-3 beta-A20-C/EBP beta in alveolar macrophages, which represents a target that may provide a promising treatment strategy for pulmonary fibrosis.

ACTA PHARMACEUTICA SINICA B (2021)

Article Respiratory System

Integrated plasma proteomics and lung transcriptomics reveal novel biomarkers in idiopathic pulmonary fibrosis

Pitchumani Sivakumar et al.

Summary: The study identified differentially expressed biomarkers in lung tissues and plasma samples of IPF patients through RNA sequencing and proteomic profiling, which may be associated with treatment response and prognosis. These findings lay the foundation for future validation of clinically relevant IPF biomarkers across larger cohorts.

RESPIRATORY RESEARCH (2021)

Review Pharmacology & Pharmacy

Mogamulizumab: An Anti-CC Chemokine Receptor 4 Antibody for T-Cell Lymphomas

Donald C. Moore et al.

ANNALS OF PHARMACOTHERAPY (2020)

Review Immunology

Transforming growth factor-beta in tissue fibrosis

Nikolaos G. Frangogiannis

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Review Rheumatology

Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases

Boris Hinz et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

Article Oncology

Mogamulizumab in the treatment of advanced mycosis fungoides and Sezary syndrome: safety and efficacy

Daniel J. Lewis et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2020)

Editorial Material Critical Care Medicine

Update in Pulmonary Fibrosis 2018

Giacomo Sgalla et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Article Cell Biology

Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

Benjamin Ng et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Article Dermatology

CCR4 Is Critically Involved in Skin Allergic Inflammation of BALB/c Mice

Kazuhiko Matsuo et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

Article Medicine, Research & Experimental

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

Chiara Berlato et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Immunology

CCR4 and its ligands: from bench to bedside

Osamu Yoshie et al.

INTERNATIONAL IMMUNOLOGY (2015)

Review Immunology

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

Jason W. Griffith et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

Article Gastroenterology & Hepatology

CCL17 Promotes Intestinal Inflammation in Mice and Counteracts Regulatory T Cell-Mediated Protection From Colitis

Alexander F. Heiseke et al.

GASTROENTEROLOGY (2012)

Article Allergy

Phenotypic characterization of lung macrophages in asthmatic patients: Overexpression of CCL17

Karl J. Staples et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

Article Medicine, Research & Experimental

CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice

Christian Weber et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Pharmacology & Pharmacy

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

Carol Kilkenny et al.

BRITISH JOURNAL OF PHARMACOLOGY (2010)

Article Biochemistry & Molecular Biology

Expression of MDC/CCL22 and its receptor CCR4 in rheumatoid arthritis, psoriatic arthritis and osteoarthritis

Helene Aarslev Flytlie et al.

CYTOKINE (2010)

Article Critical Care Medicine

Serum CC-Chemokine Ligand 18 Concentration Predicts Outcome in Idiopathic Pulmonary Fibrosis

Antje Prassel et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009)

Review Biochemistry & Molecular Biology

Chemotaxis, chemokine receptors and human disease

Tian Jin et al.

CYTOKINE (2008)

Review Immunology

Chemokines and leukocyte traffic

Federica Sallusto et al.

NATURE IMMUNOLOGY (2008)

Article Immunology

CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli

Yuichiro Tsunemi et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2006)

Article Medicine, Research & Experimental

Elevation of macrophage-derived chemokine in eosinophilic pneumonia : a role of alveolar macrophages

Kazuyoshi Manabe et al.

JOURNAL OF MEDICAL INVESTIGATION (2005)

Article Respiratory System

CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis

T Inoue et al.

EUROPEAN RESPIRATORY JOURNAL (2004)

Article Immunology

The role of the Th2CC chemokine ligand CCL17 in pulmonary fibrosis

JA Belperio et al.

JOURNAL OF IMMUNOLOGY (2004)