Musclin attenuates lipid deposition in hepatocytes through SIRT7/ autophagy-mediated suppression of ER stress

Article Pharmacology & Pharmacy

Valdecoxib attenuates lipid-induced hepatic steatosis through autophagy-mediated suppression of endoplasmic reticulum stress

Seung Yeon Park et al.

Summary: Valdecoxib (VAL) suppresses lipid accumulation in hepatocytes and alleviates hepatic steatosis through the AMPK/SIRT6 pathway. These findings suggest the potential of VAL as a therapeutic agent for non-alcoholic fatty liver disease.

BIOCHEMICAL PHARMACOLOGY (2022)

Add to Collection

Article Pharmacology & Pharmacy

Resolvin D3 improves the impairment of insulin signaling in skeletal muscle and nonalcoholic fatty liver disease through AMPK/autophagy-associated attenuation of ER stress

Heeseung Oh et al.

Summary: This study found that RD3 alleviates insulin resistance in skeletal muscle and hepatic steatosis through the AMPK/autophagy signaling pathway, providing a new therapeutic approach for treating metabolic disorders.

BIOCHEMICAL PHARMACOLOGY (2022)

Add to Collection

Article Cell Biology

Sclerostin aggravates insulin signaling in skeletal muscle and hepatic steatosis via upregulation of ER stress by mTOR-mediated inhibition of autophagy under hyperlipidemic conditions

Heeseung Oh et al.

Summary: This study found that SCL expression levels are elevated in obese patients and mice fed a high-fat diet. Furthermore, SCL was found to be associated with skeletal muscle insulin resistance and hepatic steatosis. The findings suggest that antagonizing SCL may be a novel therapeutic strategy for managing insulin resistance and hepatic steatosis in obesity.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

Add to Collection

Article Gastroenterology & Hepatology

Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4α

Huihui Ren et al.

Summary: The study showed that SIRT2 is significantly down-regulated in patients with NAFLD and HFD-induced NAFLD mice, restoring its expression in the liver can alleviate insulin resistance, hepatic steatosis, and systemic inflammation. Targeting the SIRT2-HNF4 alpha pathway may be a promising strategy for NAFLD treatment.

HEPATOLOGY (2021)

Add to Collection

Review Medicine, General & Internal

Oxidative Stress in Non-alcoholic Fatty Liver Disease. An Updated Mini Review

Anna Pia Delli Bovi et al.

Summary: This article discusses the interplay between oxidative stress and other pathogenic factors in non-alcoholic fatty liver disease (NAFLD), emphasizing the importance of reactive oxygen species (ROS) in NAFLD progression. It also points out the effectiveness of healthy diet and physical activity in NAFLD treatment, but lack of compliance, and the potential of precision medicine in selecting the best treatment for specific patients.

FRONTIERS IN MEDICINE (2021)

Add to Collection

Review Endocrinology & Metabolism

Endoplasmic Reticulum Stress and Autophagy in the Pathogenesis of Non-alcoholic Fatty Liver Disease (NAFLD): Current Evidence and Perspectives

Christina-Maria Flessa et al.

Summary: The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) are closely related to endoplasmic reticulum (ER) stress and autophagy processes, which have emerged as promising targets for therapeutic interventions. Current research focuses on finding natural/chemical compounds and drugs that can modulate these pathways to attenuate NAFLD progression. Further investigation into the interaction between ER stress, autophagy, inflammatory responses, and apoptotic mechanisms may lead to the development of more effective therapeutic options for NAFLD.

CURRENT OBESITY REPORTS (2021)

Add to Collection

Article Oncology