Transition-metal-catalyzed domino reactions of strained bicyclic alkenes

This review presents a comprehensive overview of transition-metal-catalyzed domino reactions of strained bicyclic alkenes, including both homo- and heterobicyclic alkenes. These compounds are important synthons in organic synthesis, providing an important platform for the construction of biologically/medicinally significant compounds which bear multiple stereocenters. The review has been divided according to the metal used in the reaction. An overview of the substrate scope, reaction conditions, and their potential applications in organic synthesis is discussed. A comprehensive outlook on the reactivity paradigms of homo- and heterobicyclic alkenes is discussed and should shed light on future directions for further development in this field.

Automated summary

This review provides a comprehensive overview of transition-metal-catalyzed domino reactions of strained bicyclic alkenes, including both homo- and heterobicyclic alkenes. These compounds serve as important building blocks in organic synthesis, enabling the construction of biologically/medicinally relevant compounds with multiple stereocenters. The review is categorized based on the metal used in the reaction, and discusses the substrate scope, reaction conditions, and potential applications in organic synthesis. It also presents a comprehensive outlook on the reactivity paradigms of homo- and heterobicyclic alkenes, offering insights into future directions for further advancement in this field.