Pyridine C(sp2)-H bond functionalization under transition-metal and rare earth metal catalysis

Pyridine is a crucial heterocyclic scaffold that is widely found in organic chemistry, medicines, natural products, and functional materials. In spite of the discovery of several methods for the synthesis of functionalized pyridines or their integration into an organic molecule, new methodologies for the direct functionalization of pyridine scaffolds have been developed during the past two decades. In addition, transition-metal-catalyzed C-H functionalization and rare earth metal-catalyzed reactions have flourished over the past two decades in the development of functionalized organic molecules of concern. In this review, we discuss recent achievements in the transition-metal and rare earth metal-catalyzed C-H bond functionalization of pyridine and look into the mechanisms involved.

Automated summary

Pyridine is a critical heterocyclic scaffold widely used in organic chemistry, medicines, natural products, and functional materials. New methodologies for the direct functionalization of pyridine scaffolds have been developed in the past two decades, including transition-metal-catalyzed C-H functionalization and rare earth metal-catalyzed reactions. This review discusses recent achievements in these areas and explores the underlying mechanisms.