Associations of genetically determined lipid traits and lipid-modifying agents with the risk of diabetic retinopathy: A Mendelian randomization study

Article Hematology

Pharmacological Inhibition of CETP (Cholesteryl Ester Transfer Protein) Increases HDL (High-Density Lipoprotein) That Contains ApoC3 and Other HDL Subspecies Associated With Higher Risk of Coronary Heart Disease

Jeremy D. Furtado et al.

Summary: This study suggests that increasing HDL by inhibiting CETP does not reduce the risk of cardiovascular disease but instead increases the levels of dysfunctional HDL subspecies associated with higher risk.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2022)

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Review Endocrinology & Metabolism

Lipids, hyperreflective crystalline deposits and diabetic retinopathy: potential systemic and retinal-specific effect of lipid-lowering therapies

Alicia J. Jenkins et al.

Summary: Clinical studies provide limited and sometimes conflicting evidence on the relationship between circulating lipid levels and the development of diabetic retinopathy. Trials focused on the cardiovascular system suggest that lipid-lowering therapies may have a protective effect, but trials with ocular primary endpoints are still ongoing.

DIABETOLOGIA (2022)

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Article Medicine, General & Internal

The relationship between lipoprotein A and other lipids with prostate cancer risk: A multivariable Mendelian randomisation study

Anna G. Ioannidou et al.

Summary: This study aimed to investigate the relationship between blood lipids and prostate cancer risk, and found that genetically predicted Lp(a) concentrations were associated with an increased risk of PCa, while no significant associations were observed for other lipid concentrations.

PLOS MEDICINE (2022)

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Article Endocrinology & Metabolism

HDL cholesterol is a protective predictor in the development and progression of retinopathy in type 1 diabetes: A 15-year follow-up study

Martina Tomic et al.

Summary: The aim of this study was to evaluate the 15-year incidence and progression of diabetic retinopathy (DR) in type 1 diabetic patients (T1DM) and identify associated risk factors. The results showed that the risk of DR development and progression was associated with HbA1c, urinary albumin excretion rate (AER), and HDL cholesterol levels.

DIABETES RESEARCH AND CLINICAL PRACTICE (2022)

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Editorial Material Medicine, General & Internal

Collider Bias

Mathias J. Holmberg et al.

Summary: This JAMA Guide to Statistics and Methods explains collider bias, provides examples in directed acyclic graphs, and discusses how it can impact the internal validity of a study and accurate estimation of causal relationships in randomized clinical trials and observational studies.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Editorial Material Ophthalmology

Why Is Continued Vision Loss Still a Problem in Some Patients With Diabetic Retinopathy, Despite Treatment?

Susan B. Bressler et al.

JAMA OPHTHALMOLOGY (2022)

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Article Immunology

Association Between Increased Lipid Profiles and Risk of Diabetic Retinopathy in a Population-Based Case-Control Study

Zhenzhen Liu et al.

Summary: There is an association between lipid profiles and diabetic retinopathy, and lipid level control is important for prevention and treatment of the disease, especially in younger adults and patients with good blood sugar control.

JOURNAL OF INFLAMMATION RESEARCH (2022)

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Article Pharmacology & Pharmacy

Dyslipidemia and diabetes mellitus: Role of lipoprotein species and interrelated pathways of lipid metabolism in diabetes mellitus

John P. Kane et al.

Summary: Diabetes mellitus is a complex disease with various subphenotypes including mitochondrial disorders and lipodystrophies. Insights into its molecular mechanisms may lead to better therapeutic approaches. Both diabetes and dyslipidemia are associated with increased risk for atherosclerotic vascular disease.

CURRENT OPINION IN PHARMACOLOGY (2021)

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Review Ophthalmology

Global Prevalence of Diabetic Retinopathy and Projection of Burden through 2045 Systematic Review and Meta-analysis

Zhen Ling Teo et al.

Summary: The translated paragraphs provide updated estimates on the global prevalence and number of people with diabetic retinopathy (DR) through 2045. The burden of DR is expected to increase disproportionately in countries in the Middle East and North Africa and the Western Pacific by 2045. Certain ethnic groups such as Hispanics and Middle Easterners with diabetes are more likely to have DR compared to Asians.

OPHTHALMOLOGY (2021)

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Article Ophthalmology