Journal
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1111/ajco.13932
Keywords
131I-rituximab; follicular lymphoma; mantle cell lymphoma; phase II trial; radioimmunotherapy
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This study evaluated the safety and efficacy of I-131-rituximab in patients with relapsed or refractory follicular or mantle cell lymphoma. 24 patients were enrolled, and treatment response was assessed with contrast-enhanced 18F-fluorodeoxyglucose positron emission tomography/computed tomography. The results showed that I-131-rituximab had an effective and favorable safety profile, with a median progression-free survival of 5.9 months and overall survival of 37.9 months.
AimThis study aimed to evaluate the safety and efficacy of I-131-rituximab in patients with relapsed or refractory follicular or mantle cell lymphoma. MethodsTwenty-four patients with relapsed or refractory follicular or mantle cell lymphoma were administered unlabeled rituximab (70 mg) immediately before receiving a therapeutic dose of I-131-rituximab. Contrast-enhanced 18F-fluorodeoxyglucose positron emission tomography/computed tomography was used a month later to assess tumor response. ResultsThis study enrolled 24 patients between June 2012 and 2022. Depending on how they responded to radioimmunotherapy (RIT), I-131-rituximab was administered one to five times. Of the 24 patients, 9 achieved complete response after RIT and 8 achieved partial response. The median progression-free and overall survival was 5.9 and 37.9 months, respectively. During the follow-up period of 64.2 months, three patients were diagnosed with a secondary malignancy. Among treatment-related adverse events, hematologic toxicities were common, and grade 3-4 thrombocytopenia and neutropenia were reported in 66.6% of cases. Conclusion(131)I-rituximab has an effective and favorable safety profile in patients with relapsed or refractory follicular lymphoma and mantle cell lymphoma. This suggests that RIT may also be considered a treatment option for patients with relapsed or refractory follicular lymphoma and mantle cell lymphoma.
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