Lipopolysaccharide effects on activation and apoptosis of primordial ovarian follicles in heifers

The objective of the present study was to evaluate the effect of lipopolysaccharide (LPS) administration on activation and apoptosis of primordial follicles. There was no difference in the total number of follicles as well as in the different types of follicles. Furthermore, the LPS challenge didn't modulate the expression of genes related with ovarian reserve (HAM), oocyte survival (Survivin), activation rate (Pten, KIT, KITL1, KITL2, AKT1, SIRT1), and follicular abnormalities. Therefore, the LPS exposure with 24h interval had no effect on activation rate and primordial follicles abnormalities, and also had no effect on expression of anti-apoptotic genes and genes related with ovarian reserve, oocyte survival, activation rate, and primordial follicles abnormalities.

Automated summary

The objective of this study was to evaluate the effect of lipopolysaccharide (LPS) administration on activation and apoptosis of primordial follicles. The results showed no difference in the total number of follicles and different types of follicles. Furthermore, LPS challenge did not modulate the expression of genes related to ovarian reserve, oocyte survival, activation rate, and follicular abnormalities.