Ten-Year Cohort Study of Emotional Distress Trajectories After Moderate-Severe Traumatic Brain Injury

Objective: To characterize trajectories of emotional distress across the first decade after moderate-severe traumatic brain injury (TBI) and explore relations with personal and injury-related factors.Design: Cohort study with follow-ups at 1, 2, 3, 5, and 10 years post-injury.Setting: Community.Participants: Participants were sampled from a larger longitudinal study of 4300 individuals recruited from consecutive inpatient TBI admissions to a rehabilitation hospital between 1985 and 2021 (N=4300). We analyzed data from 596 unique individuals (13.86% of total dataset; 70.81% male; Mage=40.11 years, SDage=17.49 years; 7.59% non-English-speaking background) with moderate-severe TBI who had complete data on all personal and injury-related variables (collected on admission) and emotional data at 3 or more time-points. There were 464 participants at the 1 -year post-injury time-point, 485 at 2 years, 454 at 3 years, 450 at 5 years, and 248 at 10 years.Interventions: Not applicable. Main Outcome Measure: The Hospital Anxiety and Depression Scale (HADS).Results: Visualization of the individual HADS symptoms (line graph) showed that the most highly endorsed symptoms at each time-point were feeling slowed down and restlessness. On average, each symptom reduced across the first decade post-TBI, with an overall mild level of emotional distress at 10 years. However, visualization of participants' individual trajectories based on the HADS total score (Sankey diagram) revealed sig-nificant heterogeneity. Using latent class analysis, we identified 5 distinct trajectory types based on the HADS total score: Gradual Improving (38.93%), Resilience (36.41%), Gradual Worsening (10.40%), and 2 non-linear trajectories of Worsening-Remitting (8.22%) and Improving-Relapsing (6.04%). Middle age at injury, lower Glasgow Coma Scale score, comorbid spinal and limb injuries, and receipt of pre -injury mental health treatment predicted earlier and/or worsening post-injury emotional distress.Conclusions: Emotional distress across the first decade after moderate-severe TBI is dynamic, heterogeneous, and often chronic, underscoring a need for ongoing monitoring and responsive treatment. Archives of Physical Medicine and Rehabilitation 2023;104:1081-90 & COPY; 2023 by the American Congress of Rehabilitation Medicine.

Automated summary

Objective of this study was to characterize trajectories of emotional distress across the first decade after moderate-severe traumatic brain injury (TBI) and explore relations with personal and injury-related factors. Results revealed that emotional distress is dynamic, heterogeneous, and often chronic during the first decade post-TBI, underscoring the need for ongoing monitoring and responsive treatment.