Recent Advances in Machine Learning-Based Models for Prediction of Antiviral Peptides

Viruses have killed and infected millions of people across the world. It causes several chronic diseases like COVID-19, HIV, and hepatitis. To cope with such diseases and virus infections, antiviral peptides (AVPs) have been applied in the design of drugs. Keeping in view the significant role in pharmaceutical industry and other research fields, identification of AVPs is highly indispensable. In this connection, experimental and computational methods were proposed to identify AVPs. However, more accurate predictors for boosting AVPs identification are highly desirable. This work presents a thorough study and reports the available predictors of AVPs. We explained applied datasets, feature representation approaches, classification algorithms, and evaluation parameters of performance. In this study, the limitations of the existing studies and the best methods were emphasized. Provided the pros and cons of the applied classifiers. The future insights demonstrate efficient feature encoding approaches, best feature optimization schemes, and effective classification techniques that can improve the performance of novel method for accurate prediction of AVPs.

Automated summary

Viruses like COVID-19, HIV, and hepatitis have caused illness and death on a global scale. Antiviral peptides (AVPs) have been used to develop drugs for these diseases, and accurate prediction of AVPs is crucial. This study thoroughly examines existing predictors of AVPs, discussing datasets, feature representation methods, classification algorithms, and evaluation parameters. It also highlights limitations of current studies and suggests future improvements for more accurate AVP prediction.