Preparation of [68Ga]Ga-Chloride from 68Zn solid target for the synthesis of pharmaceutical grade [68Ga]Ga-PSMA-11 and [68Ga]Ga-DOTA-TATE

Article Oncology

Cyclotron vs generator-produced 68Ga PSMA: a single-institution, prospective clinical trial

Juana Martinez et al.

Summary: This study evaluates the equivalence between two manufacturing processes for 68Ga-PSMA: 68Ga-PSMA-cyclotron and 68Ga-PSMA-generator. The results suggest that both methods yield similar results in detecting PSMA+ lesions, indicating the potential of cyclotron-produced 68Ga-PSMA for large-scale production, cost reduction, and increased availability of the radioisotope for future use.

TRANSLATIONAL ONCOLOGY (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Demystifying solid targets: Simple and rapid distribution-scale production of [68Ga]GaCl3 and [68Ga]Ga-PSMA-11

Johan Svedjehed et al.

Summary: The study focused on a fully automated solid target production and purification process with a simplified chemistry execution using a single time-list. High activity productions of [Ga-68]GaCl3 achieved a high purification yield with good radiochemical yields, while [Ga-68]Ga-PSMA-11 productions also showed promising results in terms of yield and purity.

NUCLEAR MEDICINE AND BIOLOGY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

A Comprehensive Assessment of 68Ga-PSMA-11 PET in Biochemically Recurrent Prostate Cancer: Results from a Prospective Multicenter Study on 2,005 Patients

Monica Abghari-Gerst et al.

Summary: This study prospectively investigated the performance of prostate adenocarcinoma in patients with elevated PSA levels after initial therapy. The results showed that 68GaPSMA-11 PET can accurately detect the presence and disease burden of prostate cancer in patients who have undergone different treatments.

JOURNAL OF NUCLEAR MEDICINE (2022)

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Article Biochemical Research Methods

Synthesis of 68Ga-radiopharmaceuticals using both generator-derived and cyclotron-produced 68Ga as exemplified by [68Ga]Ga-PSMA-11 for prostate cancer PET imaging

Melissa E. Rodnick et al.

Summary: [Ga-68]Ga-PSMA-11, a radiopharmaceutical approved for prostate cancer PET imaging, is in high demand. This study presents synthesis methods for [Ga-68]Ga-PSMA-11 using generator-eluted and cyclotron-produced Ga-68. Both methods are suitable for clinical production, but the cyclotron method is more promising for meeting high patient volumes in the long term.

NATURE PROTOCOLS (2022)

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Article Chemistry, Inorganic & Nuclear

Cyclotron-produced 68Ga from enriched 68Zn foils

Jonathan Siikanen et al.

Summary: The study focuses on the growing demand and limited availability of 68Ga for PET scans, proposing an alternative high-output production method using PET cyclotrons, and aims to expand production capacity by using enriched 68Zn foils.

APPLIED RADIATION AND ISOTOPES (2021)

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Article Chemistry, Medicinal

Multi-curie production of gallium-68 on a biomedical cyclotron and automated radiolabelling of PSMA-11 and DOTATATE

Helge Thisgaard et al.

Summary: In response to the increasing clinical demand for gallium-68, a high-yield, automated method has been developed for producing multi-Curie levels of [Ga-68]GaCl3 from solid zinc-68 targets. This method led to record-high purified gallium-68 activities and successful labelling of PSMA-11 and DOTATATE, showing promising results for clinical use in terms of quality control.

EJNMMI RADIOPHARMACY AND CHEMISTRY (2021)

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Article Chemistry, Inorganic & Nuclear