Journal
ADVANCED MATERIALS
Volume 27, Issue 9, Pages 1593-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201404677
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Funding
- Stand Up to Cancer
- Howard Hughes Medical Institute
- NIH [CA129933, P41 EB002503-11]
- National Institute for Biomedical Imaging and Bioengineering (NIBIB) [EB008047]
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A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress.
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