Journal
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Volume 68, Issue 16, Pages 1785-1803Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2016.06.072
Keywords
cardiovascular disease; diabetes; hypertension; lifestyle medicine; network; obesity; systems biology
Categories
Funding
- Novo Nordisk
- Eisai
- Janssen
- Vivus
- Takeda
- AstraZeneca
- Alexion
- Merck
Ask authors/readers for more resources
Adipokines are peptides, secreted by adipocytes and other cell types with targets in other tissues, participating in a complex network of humoral factors involved in obesity, insulin resistance, and cardiovascular (CV) disease. This review describes recent information about adipokine effects on the CV system. Rather than simply providing a listing of adipokines and their respective effects, network analysis is used to enhance understanding. Various relationships and emergent processes in the adipokine-CV system network are discussed, with the most significant interactors being responses to hypoxia, regulation of cell migration, effects on blood coagulation, and platelet activation. Clinical translation is provided through network representations of the obesity paradox, metabolically healthy obese, metabolic syndrome, and beneficial role of lifestyle medicine. As more translatable information about the larger adipokine-CV-lifestyle network is acquired from laboratory and clinical research, the strategic and precise role of lifestyle intervention can be fashioned to improve CV outcomes. (C) 2016 by the American College of Cardiology Foundation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available