☆ 4.3 Article

Locally performed postoperative circulating tumour DNA testing performed during routine clinical care to predict recurrence of colorectal cancer

ANZ JOURNAL OF SURGERY (2023)

Related references

Note: Only part of the references are listed.

Article Multidisciplinary Sciences

Identification of TP53 mutations in circulating tumour DNA in high grade serous ovarian carcinoma using next generation sequencing technologies

Leslie Calapre et al.

Summary: This study compared the suitability of the Accel and Oncomine panels for identification of TP53 mutations in ctDNA of HGSOC patients. Results showed that only 60% of patients were found to have TP53 mutations using the Accel panel, but the addition of molecular tags in the Oncomine panel improved ctDNA detection with at least one mutation detected in all cases. Orthogonal validation using droplet digital PCR confirmed 79% of the identified mutations. Overall, the Oncomine panel with unique molecular identifiers (UMI) appears more useful for ctDNA analysis in HGSOC.

SCIENTIFIC REPORTS (2023)

Add to Collection

Article Oncology

Circulating Tumor DNA in Stage III Colorectal Cancer, beyond Minimal Residual Disease Detection, toward Assessment of Adjuvant Therapy Efficacy and Clinical Behavior of Recurrences

Tenna Vesterman Henriksen et al.

Summary: The study demonstrates the strong prognostic value of serial postoperative ctDNA analysis in predicting recurrence and assessing tumor growth rate. The novel combination of ctDNA detection and growth rate assessment provides unique opportunities for guiding treatment decisions.

CLINICAL CANCER RESEARCH (2022)

Add to Collection

Review Biochemistry & Molecular Biology

A clinician's handbook for using ctDNA throughout the patient journey

Samantha O. Hasenleithner et al.

Summary: The analysis of cell-free DNA from liquid biopsy, particularly circulating tumor DNA (ctDNA), has shown promise in oncology, but questions remain regarding its clinical validity and utility, necessitating further research and study.

MOLECULAR CANCER (2022)

Add to Collection

Article Medicine, General & Internal

Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer

Jeanne Tie et al.

Summary: This study found that using ctDNA results to guide treatment decisions for stage II colon cancer reduced the use of adjuvant chemotherapy without compromising recurrence-free survival.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Add to Collection

Article Oncology

Prognostic significance of postsurgery circulating tumorDNAin nonmetastatic colorectal cancer: Individual patient pooled analysis of three cohort studies

Jeanne Tie et al.

Summary: Studies have shown that postoperative ctDNA analysis is prognostically significant in nonmetastatic CRC patients, with higher predictive accuracy for recurrence compared to clinicopathologic risk factors, and increasing mutant allele frequency (MAF) further stratifying recurrence risk.

INTERNATIONAL JOURNAL OF CANCER (2021)

Add to Collection

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Add to Collection

Article Oncology

Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer

Aparna R. Parikh et al.

Summary: The study demonstrates that detection of persistent circulating tumor DNA in plasma shows favorable sensitivity and specificity for predicting recurrence after curative-intent surgery for colorectal cancer. Integrating analysis of genomic and epigenomic signatures enhances the accuracy of detection, supporting the potential clinical utility of plasma-only ctDNA minimal residual disease detection.

CLINICAL CANCER RESEARCH (2021)

Add to Collection

Article Oncology

Postoperative circulating tumor DNA as markers of recurrence risk in stages II to III colorectal cancer

Gong Chen et al.

Summary: This study found that postoperative detection of circulating tumor DNA (ctDNA) can predict high relapse risk and identify disease recurrence ahead of radiological imaging in patients with stage II/III colorectal cancer (CRC). ctDNA may be used to guide decision-making in postoperative management.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Add to Collection

Article Medicine, General & Internal

Circulating tumor DNA dynamics and recurrence risk in patients undergoing curative intent resection of colorectal cancer liver metastases: A prospective cohort study

Jeanne Tie et al.

Summary: Serial ctDNA analysis in patients with resectable CRLM can serve as an early marker of treatment efficacy during adjuvant chemotherapy, aiding in the optimal use of perioperative chemotherapy. The prognostic impact of postoperative and posttreatment ctDNA in resected CRLM patients has been confirmed, highlighting the need for further studies on integrating ctDNA analyses into decision-making regarding adjuvant therapy for resectable CRLM.

PLOS MEDICINE (2021)

Add to Collection

Article Oncology

MRI Tumor Regression Grade and Circulating Tumor DNA as Complementary Tools to Assess Response and Guide Therapy Adaptation in Rectal Cancer

Shelize Khakoo et al.

CLINICAL CANCER RESEARCH (2020)

Add to Collection

Article Oncology

The effect of surgical trauma on circulating free DNA levels in cancer patients-implications for studies of circulating tumor DNA

Tenna V. Henriksen et al.

MOLECULAR ONCOLOGY (2020)

Add to Collection

Article Gastroenterology & Hepatology

Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study

Jeanne Tie et al.

GUT (2019)

Add to Collection

Meeting Abstract Oncology

Clonal hematopoiesis of indeterminate potential (CHIP) mutations in solid tumor malignancies.

Madison Conces et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

Add to Collection

Article Oncology

Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer

Thomas Reinert et al.

JAMA ONCOLOGY (2019)

Add to Collection

Article Oncology

RAS and BRAF mutations in cell-free DNA are predictive for outcome of cetuximab monotherapy in patients with tissue-tested RAS wild-type advanced colorectal cancer

Erik J. van Helden et al.

MOLECULAR ONCOLOGY (2019)

Add to Collection

Article Oncology

Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer

N. Tarazona et al.

ANNALS OF ONCOLOGY (2019)

Add to Collection

Article Oncology

Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Benefit of Adjuvant Therapy for Stage III Colon Cancer

Jeanne Tie et al.

JAMA ONCOLOGY (2019)

Add to Collection

Article Oncology

Clinical Implications of Monitoring Circulating Tumor DNA in Patients with Colorectal Cancer

Lone V. Scholer et al.

CLINICAL CANCER RESEARCH (2017)

Add to Collection

Article Cell Biology

Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

Jeanne Tie et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Add to Collection

Review Gastroenterology & Hepatology

Accuracy of TNM staging in colorectal cancer: a review of current culprits, the modern role of morphology and stepping-stones for improvements in the molecular era

Dordi Lea et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2014)

Add to Collection

Review Oncology

Early Detection of Colorectal Cancer Recurrence in Patients Undergoing Surgery with Curative Intent: Current Status and Challenges

Patrick. E. Young et al.

JOURNAL OF CANCER (2014)

Add to Collection

© Peeref 2019-2024. All rights reserved.