4.7 Article

Antiviral activity of the HSP90 inhibitor VER-50589 against enterovirus 71

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Enterovirus A71 antivirals: Past, present, and future

Jun Wang et al.

Summary: Enterovirus A71 (EV-A71) is a significant human pathogen that particularly affects children. Existing vaccines for EV-A71 have limited protection and reduced efficacy against emerging strains. No approved antiviral for EV-A71 is currently available. Researchers have made progress in developing antivirals by targeting viral proteins and host factors, although some approaches have shown limited efficacy or side effects.

ACTA PHARMACEUTICA SINICA B (2022)

Review Biochemistry & Molecular Biology

Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Zhen Luo et al.

Summary: This paper provides a systematic review of the mechanisms of hypoxia signaling activation, the control of HIF signaling, and the function of HIF signaling in human health and diseases. The therapeutic targets involved in balancing health and diseases are also summarized, offering novel strategies for therapeutic drug design and development.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Article Pharmacology & Pharmacy

Isocotoin suppresses hepatitis E virus replication through inhibition of heat shock protein 90

Ila Nimgaonkar et al.

Summary: Hepatitis E virus (HEV) is a significant global health threat, causing millions of infections and thousands of deaths each year, particularly dangerous for immunocompromised individuals and pregnant women. A compound called isocotoin has been found to inhibit HEV replication by targeting heat shock protein 90 (HSP90), opening up new possibilities for developing effective therapies against HEV.

ANTIVIRAL RESEARCH (2021)

Article Biochemistry & Molecular Biology

Evolution of kinase polypharmacology across HSP90 drug discovery

Albert A. Antolin et al.

Summary: This study identified and systematically characterized the kinase cross-pharmacology of representative HSP90 inhibitors using computational and experimental methods, revealing unique off-target kinase pharmacology of certain clinical candidates. It was also shown that polypharmacology evolved during optimization to discover luminespib, with hit, leads, and clinical candidate having different profiles. The study recommends early computational and experimental characterization of polypharmacology in drug discovery projects to uncover new opportunities for multi-target drug design.

CELL CHEMICAL BIOLOGY (2021)

Review Chemistry, Multidisciplinary

Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses

Yue Ma et al.

Summary: This article discusses strategies for discovering antiviral compounds specifically designed to combat drug resistance, including targeting proteins, drug conformation, new binding sites, and host factors as potential therapeutic approaches.

CHEMICAL SOCIETY REVIEWS (2021)

Article Pharmacology & Pharmacy

Emetine protects mice from enterovirus infection by inhibiting viral translation

Qi Tang et al.

ANTIVIRAL RESEARCH (2020)

Review Microbiology

Host-Directed Antiviral Therapy

Naveen Kumar et al.

CLINICAL MICROBIOLOGY REVIEWS (2020)

Article Gastroenterology & Hepatology

Molecular characteristics of the VP1 region of enterovirus 71 strains in China

Haiyan Sun et al.

GUT PATHOGENS (2020)

Article Multidisciplinary Sciences

Chaperone-mediated autophagy is involved in the execution of ferroptosis

Zheming Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

Type III interferon signaling restricts enterovirus 71 infection of goblet cells

Charles Good et al.

SCIENCE ADVANCES (2019)

Article Multidisciplinary Sciences

Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects

Phuong A. Nguyen et al.

NATURE COMMUNICATIONS (2019)

Review Virology

HSP90: a promising broad-spectrum antiviral drug target

Yiliang Wang et al.

ARCHIVES OF VIROLOGY (2017)

Review Environmental Sciences

The Current Status of the Disease Caused by Enterovirus 71 Infections: Epidemiology, Pathogenesis, Molecular Epidemiology, and Vaccine Development

Ping-Chin Chang et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2016)

Article Multidisciplinary Sciences

Heat shock protein 90 controls HIV-1 reactivation from latency

Ian Anderson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Infectious Diseases

A Repurposing Strategy for Hsp90 Inhibitors Demonstrates Their Potency against Filarial Nematodes

Victoria Gillan et al.

PLOS NEGLECTED TROPICAL DISEASES (2014)

Review Cell Biology

Recent developments in antiviral agents against enterovirus 71 infection

Chee Wah Tan et al.

JOURNAL OF BIOMEDICAL SCIENCE (2014)

Article Pharmacology & Pharmacy

MEK1-ERKs signal cascade is required for the replication of Enterovirus 71 (EV71)

Bo Wang et al.

ANTIVIRAL RESEARCH (2012)

Article Virology

Virus-host interactomes - antiviral drug discovery

Yue Ma-Lauer et al.

CURRENT OPINION IN VIROLOGY (2012)

Review Biochemistry & Molecular Biology

Systematic Approaches towards the Development of Host-Directed Antiviral Therapeutics

Andrew Prussia et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2011)

Article Biochemistry & Molecular Biology

Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor

Miguel A. Mata et al.

NATURE CHEMICAL BIOLOGY (2011)

Article Pharmacology & Pharmacy

Inhibition of heat-shock protein 90 reduces Ebola virus replication

Darci R. Smith et al.

ANTIVIRAL RESEARCH (2010)

Review Infectious Diseases

Virology, epidemiology, pathogenesis, and control of enterovirus 71

Tom Solomon et al.

LANCET INFECTIOUS DISEASES (2010)

Article Biochemistry & Molecular Biology

Regulation of TopBP1 oligomerization by Akt/PKB for cell survival

Kang Liu et al.

EMBO JOURNAL (2006)

Article Biochemistry & Molecular Biology

Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90

Toru Okamoto et al.

EMBO JOURNAL (2006)

Article Multidisciplinary Sciences

Modulation of Akt kinase activity by binding to Hsp90

S Sato et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)