Major Gaps in Understanding Dietary Supplement Use in Health and Disease

Precise dietary assessment is critical for accurate exposure classification in nutritional research, typically aimed at understanding how diet relates to health. Dietary supplement (DS) use is widespread and represents a considerable source of nutrients. However, few studies have compared the best methods to measure DSs. Our literature review on the relative validity and reproducibility of DS instruments in the United States [e.g., product inventories, questionnaires, and 24-h dietary recalls (24HR)] identified five studies that examined validity (n = 5) and/or reproducibility (n = 4). No gold standard reference method exists for validating DS use; thus, each study's investigators chose the reference instrument used to measure validity. Self-administered questionnaires agreed well with 24HR and inventory methods when comparing the prevalence of commonly used DSs. The inventory method captured nutrient amounts more accurately than the other methods. Reproducibility (over 3 months to 2.4 years) of prevalence of use estimates on the questionnaires was acceptable for common DSs. Given the limited body of research on measurement error in DS assessment, only tentative conclusions on these DS instruments can be drawn at present. Further research is critical to advancing knowledge in DS assessment for research and monitoring purposes.

Automated summary

Precise dietary assessment is crucial in nutritional research to understand the relationship between diet and health. This study reviewed five studies on the validity and reproducibility of dietary supplement instruments in the United States. Self-administered questionnaires agreed well with 24-hour dietary recalls and product inventories in assessing the prevalence of commonly used dietary supplements. The inventory method was found to be more accurate in measuring nutrient amounts. Further research is needed to advance knowledge in the assessment of dietary supplements.