Journal
CELLULAR SIGNALLING
Volume 27, Issue 10, Pages 2131-2136Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2015.06.003
Keywords
Schizophrenia; Epigenetics; Antipsychotics; Histone deacetylases (HDACs); Histones
Categories
Funding
- National Institute of Mental Health [R01MH084894]
- postdoctoral fellowships from the Japan Society for the Promotion of Science (Young Scientists JSPS) [23-3454]
- Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [15H06719] Funding Source: KAKEN
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Histone modifications and DNA methylation represent central dynamic and reversible processes that regulate gene expression and contribute to cellular phenotypes. These epigenetic marks have been shown to play fundamental roles in a diverse set of signaling and behavioral outcomes. Psychiatric disorders such as schizophrenia and depression are complex and heterogeneous diseases with multiple and independent factors that may contribute to their pathophysiology, making challenging to find a link between specific elements and the underlying mechanisms responsible for the disorder and its treatment Growing evidences suggest that epigenetic modifications in certain brain regions and neural circuits represent a key mechanism through which environmental factors interact with individual's genetic constitution to affect risk of psychiatric conditions throughout life. This review focuses on recent advances that directly implicate epigenetic modifications in schizophrenia and antipsychofic drug action. Published by Elsevier Inc.
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