Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 3, Pages 962-968Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b11720
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Funding
- Swedish Research Council (VR)
- Swedish Governmental Agency for Innovation Systems (VINNOVA)
- Knut & Alice Wallenberg Foundation [3DEM-NATUR]
- Royal Swedish Academy of Sciences
- Swedish Research Council (VR) [2011-3720]
- Karolinska Institutet
- Institute of Environmental Medicine
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Many medical and chemical applications require target molecules to be delivered in a controlled manner at precise locations. Metal-organic frameworks (MOFs) have high porosity, large surface area, and tunable functionality and are promising carriers for such purposes. Current approaches for incorporating target molecules are based on multistep postfunctionalization. Here, we report a novel approach that combines MOF synthesis and molecule encapsulation in a one-pot process. We demonstrate that large drug and dye molecules can be encapsulated in zeolitic imidazolate framework (ZIF) crystals. The molecules are homogeneously distributed within the crystals, and their loadings can be tuned. We show that ZIF-8 crystals loaded with the anticancer drug doxorubicin (DOX) are efficient drug delivery vehicles in cancer therapy using pH-responsive release. Their efficacy on breast cancer cell lines is higher than that of free DOX. Our one-pot process opens new possibilities to construct multifunctional delivery systems for a wide range of applications.
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