Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 23, Pages 7256-7259Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b03780
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Funding
- NIH [R01GM113030, HL113303]
- Sloan Foundation
- NSF [CHE-1427987]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1427987] Funding Source: National Science Foundation
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Hydrogen sulfide (H2S) is an important biological signaling molecule, and chemical tools for H2S delivery and detection have emerged as important investigative methods. Key challenges in these fields include developing donors that are triggered to release H2S in response to stimuli and developing probes that do not irreversibly consume H2S. Here we report a new strategy for H2S donation based on self-immolation of benzyl thiocarbamates to release carbonyl sulfide, which is xapidly converted to H2S by carbonic anhydrase. We leverage this chemistry to develop easily modifiable donors that can be triggered to release H2S. We also demonstrate that this approach can be coupled with common H2S-sensing motifs to generate scaffolds which, upon reaction with H2S, generate a fluorescence response and also release caged H2S, thus addressing challenges of analyte homeostasis in reaction-based probes.
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