Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 35, Pages 11128-11131Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b06903
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Funding
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Major program of Development Foundation of Hefei Center for Physical Science and Technology
- Hefei Science Center CAS [2015HSC-UP012]
- National Natural Science Foundation of China [U1532144, 21375121]
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Employing cellular environment for the self-assembly of supramolecular nanofibers for biological applications has been widely explored. But using one precursor to differentiate the extra- and intracellular environments to self-assemble into two different nano fibers remains challenging. With the knowledge that the extracellualr environment of some cancer cells contains large amounts of alkaline phosphatase (ALP) while their intracellular environment is glutathione (GSH)-abundant in mind, we rationally designed a precursor Cys(SEt)-Glu-Tyr(H2PO3)-Phe-Phe-Gly-CBT (1) that can efficiently yield amphiphilic 2 and 2-D to self-assemble into two different nanofibers in hydrogels under the sequential treatment of ALP and GSH. We envision that, by employing a click condensation reaction, this work offers a platform for facilely postmodulation of supramolecular nanofibers, and the versatile precursor 1 could be used to kill two birds with one stone.
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