Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 42, Pages 13862-13865Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b09533
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Funding
- NIH NIGMS [R01 01 GM093213-01]
- Shanghai Institute of Organic Chemistry
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Alkyl oxalates, prepared from their corresponding alcohols, are engaged for the first time as carbon radical fragments in metallaphotoredox catalysis. In this report, we demonstrate that alcohols, native organic functional groups, can be readily activated with simple oxalyl chloride to become radical precursors in a net redox-neutral C-sp(3)-C-sp(2) cross-coupling with a broad range of aryl halides. This alcohol-activation coupling is successfully applied to the functionalization of a naturally occurring steroid and the expedient synthesis of a medicinally relevant drug lead.
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