4.8 Article

Asymmetric Total Synthesis of Naphthospironone A

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Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202303229

Keywords

Aldol Cyclization; Caged Structure; Naphthoquinone; Natural Products; Total Synthesis

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In this study, Naphthospironone A, a polyhydroxy cagelike bioactive natural product, was synthesized for the first time. The spiro[bicyclo[3.2.1]octane-pyran] core was constructed by an acid-promoted epoxide-opening lactonisation and a base-induced intramolecular aldol-type cyclisation.
Naphthospironone A, a polyhydroxy cagelike bioactive natural product, was synthesised for the first time in this study. The spiro[bicyclo[3.2.1]octane-pyran] core was constructed by an acid-promoted epoxide-opening lactonisation and a base-induced intramolecular aldol-type cyclisation.

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