4.8 Article

High-Throughput Optimization of Photochemical Reactions using Segmented-Flow Nanoelectrospray-Ionization Mass Spectrometry

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Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202301664

Keywords

Continuous Flow; High-Throughput Experimentation; Mass Spectrometry; Microfluidics; Photocatalysis

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In the field of drug discovery, high-throughput experimentation techniques are used to optimize reactions and generate drug compound libraries quickly for evaluation. This study presents a segmented flow mass spectrometry-based platform to explore photoredox reactions in early-stage drug discovery. The technology enables fast analysis of photochemical reactions and evaluation of synthesized analogs, expanding the capabilities of photoredox catalysis in drug discovery.
Within the realm of drug discovery, high-throughput experimentation techniques enable the rapid optimization of reactions and expedited generation of drug compound libraries for biological and pharmacokinetic evaluation. Herein we report the development of a segmented flow mass spectrometry-based platform to enable the rapid exploration of photoredox reactions for early-stage drug discovery. Specifically, microwell plate-based photochemical reaction screens were reformatted to segmented flow format to enable delivery to nanoelectrospray ionization-mass spectrometry analysis. This approach was demonstrated for the late-stage modification of complex drug scaffolds, as well as the subsequent structure-activity relationship evaluation of synthesized analogs. This technology is anticipated to expand the robust capabilities of photoredox catalysis in drug discovery by enabling high-throughput library diversification.

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