Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 38, Pages 12312-12315Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b06379
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Funding
- National Science Foundation of China [21572099, 21332005, 21290192, 21273102]
- Natural Science Foundation of Jiangsu Province [BK20151379]
- Ph.D. Programs Foundation of the Ministry of Education of China [20130091120047]
- SRF for ROCS, SEM
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For the first time, 4-alkyl Hantzsch esters were used to construct molecules with all-carbon quaternary centers by visible light-induced photoredox catalysis via transfer alkylation. Up to a 1500 h(-1) turnover frequency was achieved in this reaction. Reactions of 4-alkyl Hantzsch nitriles as tertiary radical donors joined two contiguous all-carbon quaternary centers intermolecularly, and this chemistry was used to synthesize a common precursor of a class of hydroxysteroid dehydrogenase inhibitors.
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