Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume -, Issue -, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202217995
Keywords
Cancer Therapy; Metal-Organic Frameworks; Missing Linker; Nanozymes; Self-Assembly
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Researchers develop a facile missing-linker-confined coordination strategy to fabricate two self-assembled nanozymes: conventional nanozyme (NE) and single-atomic nanozyme (SAE). They consist of Pt nanoparticles and single Pt atoms as active catalytic sites anchored in metal-organic frameworks (MOFs) with encapsulated photosensitizers for catalase-mimicking enhanced photodynamic therapy. Compared to a Pt nanoparticle-based conventional nanozyme, a Pt single-atomic nanozyme shows enhanced catalase-mimicking activity in generating oxygen for overcoming tumor hypoxia, exhibiting more efficient reactive oxygen species generation and higher tumor inhibition rate.
Conventional nanozymes often possess low active site density. Pursuing effective strategies for constructing highly active single-atomic nanosystems with maximum atom utilization efficiency is exceptionally attractive. Herein, we develop a facile missing-linker-confined coordination strategy to fabricate two self-assembled nanozymes, i.e., conventional nanozyme (NE) and single-atomic nanozyme (SAE), which respectively consist of Pt nanoparticles and single Pt atoms as active catalytic sites anchored in metal-organic frameworks (MOFs) with encapsulated photosensitizers for catalase-mimicking enhanced photodynamic therapy. Compared to a Pt nanoparticle-based conventional nanozyme, a Pt single-atomic nanozyme shows enhanced catalase-mimicking activity in generating oxygen for overcoming tumor hypoxia, thus exhibiting a more efficient reactive oxygen species generation and high tumor inhibition rate.
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