Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 7, Pages 2174-2177Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b00250
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Funding
- NIH [GM-097444]
- Bristol-Myers Squibb
- Department of Defense
- Catalan Government
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A new transformation is presented that enables chemists to couple simple alkyl carboxylic acids with aryl zinc reagents under Ni-catalysis. The success of this reaction hinges on the unique use of redox-active esters that allow one to employ such derivatives as alkyl halides surrogates. The chemistry exhibits broad substrate scope and features a high degree of practicality. The simple procedure and extremely inexpensive nature of both the substrates and pre-catalyst (NiCl2 center dot 6H(2)O, ca. $9.5/mol) bode well for the immediate widespread adoption of this method.
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