The biological interactions between kynurenine and AhR in melanocytes: in vitro studies

Kynurenine (KYN), a tryptophan metabolite, is endogenously produced by the skin cells and is present in human sweat. The aim of this study was to determine the molecular mechanism of the antiproliferative activity of KYN on human epidermal melanocytes. KYN significantly inhibited the metabolic activity of HEMa cells by decreasing cyclin D1 and cyclin-dependent kinase 4 (CDK4) levels via the aryl hydrocarbon receptor (AhR) pathway. The results suggested that KYN might be involved in the regulation of physiological and pathological processes mediated by melanocytes.

Automated summary

The aim of this study was to investigate the molecular mechanism of KYN's antiproliferative activity on human epidermal melanocytes. The results showed that KYN significantly inhibited the metabolic activity of HEMa cells by decreasing the levels of cyclin D1 and cyclin-dependent kinase 4 (CDK4) through the aryl hydrocarbon receptor (AhR) pathway. These findings suggest that KYN might play a role in regulating physiological and pathological processes mediated by melanocytes.