4.8 Article

Rapid 3D Extrusion of Synthetic Tumor Microenvironments

Journal

ADVANCED MATERIALS
Volume 27, Issue 37, Pages 5512-5517

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201501729

Keywords

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Funding

  1. National Science Foundation IGERT: Training the Next Generation of Researchers in Cellular and Molecular Mechanics and BioNanotechnology [0965918]
  2. American Cancer Society Illinois Division [281225]
  3. NIH [R00CA153914]
  4. IGB Imaging Facilities
  5. Micro and Nanotechnology Laboratory Facilities

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The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.

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