Journal
ADVANCED MATERIALS
Volume 27, Issue 37, Pages 5512-5517Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201501729
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Funding
- National Science Foundation IGERT: Training the Next Generation of Researchers in Cellular and Molecular Mechanics and BioNanotechnology [0965918]
- American Cancer Society Illinois Division [281225]
- NIH [R00CA153914]
- IGB Imaging Facilities
- Micro and Nanotechnology Laboratory Facilities
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The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.
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