☆ 4.6 Editorial Material

Alleviating graft-versus-host disease by directing regulatory T cells to the gut ... It is all about location, location, location

AMERICAN JOURNAL OF TRANSPLANTATION (2023)

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Flagellin-specific human CAR Tregs for immune regulation in IBD

Dominic A. Boardman et al.

Summary: Regulatory T cell (Treg) therapy is a promising strategy for treating inflammatory bowel disease (IBD). A novel chimeric antigen receptor (CAR) specific for flagellin derived from Escherichia coli H18 (FliC) was developed to confer FliC-specificity to human Tregs. FliC-CAR Tregs showed specificity and functionality, and demonstrated potential in treating IBD by suppressing inflammation and promoting the establishment of colon-derived epithelial cell monolayers.

JOURNAL OF AUTOIMMUNITY (2023)

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Article Surgery