Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 50, Pages 16274-16282Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b06592
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Funding
- National Science Foundation [0923395, CHE-1309817]
- National Institutes of Health [S10 RR025679]
- Robert P. Apkarian Integrated Electron Microscopy Core (RPAIEMC)
- Emory College of Arts and Sciences
- Emory University School of Medicine
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR000454]
- U.S. D.O.E. Office of Basic Energy Sciences, Division of Material Sciences [W-31-109-Eng-38]
- NSF [CHE-1012620, CHE-1412580]
- Emory University
- Children's Healthcare of Atlanta
- Georgia Research Alliance
- Center for AIDS Research at Emory University [P30 AI050409]
- James B. Pendleton Charitable Trust
- NIH [R01GM104540]
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0923395] Funding Source: National Science Foundation
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1412580] Funding Source: National Science Foundation
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Sequence-specific peptides have been demonstrated to self-assemble into structurally defined nanoscale objects including nanofibers, nanotubes, and nanosheets. The latter structures display significant promise for the construction of hybrid materials for functional devices due to their extended planar geometry. Realization of this objective necessitates the ability to control the structural features of the resultant assemblies through the peptide sequence. The design of a amphiphilic peptide, 3FD-IL, is described that comprises two repeats of a canonical 18 amino acid sequence associated with straight a-helical structures. Peptide 3FD-IL displays 3-fold screw symmetry in a helical conformation and self-assembles into nanosheets based on hexagonal packing of helices. Biophysical evidence from TEM, cryo-TEM, SAXS, AFM, and STEM measurements on the 3FD-IL nanosheets support a structural model based on a honeycomb lattice, in which the length of the peptide determines the thickness of the nanosheet and the packing of helices defines the presence of nanoscale channels that permeate the sheet. The honeycomb structure can be rationalized on the basis of geometrical packing frustration in which the channels occupy defect sites that define a periodic superlattice. The resultant 2D materials may have potential as materials for nanoscale transport and controlled release applications.
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