4.5 Article

Mutation-specific Mismatch Repair-deficient Benign Endometrial Glands in Endometrial Biopsies and Curettings Are a Biomarker of Lynch Syndrome and Associate With Endometrial Carcinoma Development

Related references

Note: Only part of the references are listed.
Article Cell Biology

DNA mismatch repair-deficient non-neoplastic endometrial glands are common in Lynch syndrome patients and are present at a higher density than in the colon

Shaymaa Hegazy et al.

Summary: Research shows that MMR-deficient non-neoplastic endometrial glands are indicative of LS, with a pattern of contiguous large groups in the endometrium.

HISTOPATHOLOGY (2021)

Article Medicine, General & Internal

Cost-effectiveness Analysis of Genotype-Specific Surveillance and Preventive Strategies for Gynecologic Cancers Among Women With Lynch Syndrome

Jason D. Wright et al.

Summary: With the expansion of multigene testing for cancer susceptibility, Lynch syndrome (LS) has become more readily identified among women. The study evaluated the cost-effectiveness of genotype-specific surveillance and preventive strategies for LS-associated gynecologic cancers, suggesting gene-specific preventive strategies may be warranted.

JAMA NETWORK OPEN (2021)

Review Medicine, General & Internal

The prevalence of Lynch syndrome in women with endometrial cancer: a systematic review protocol

Neil A. J. Ryan et al.

SYSTEMATIC REVIEWS (2018)

Article Gastroenterology & Hepatology

Colon and Endometrial Cancers With Mismatch Repair Deficiency Can Arise From Somatic, Rather Than Germline, Mutations

Sigurdis Haraldsdottir et al.

GASTROENTEROLOGY (2014)

Article Gastroenterology & Hepatology

Somatic Mutations in MLH1 and MSH2 Are a Frequent Cause of Mismatch-Repair Deficiency in Lynch Syndrome-Like Tumors

Arjen R. Mensenkamp et al.

GASTROENTEROLOGY (2014)

Review Biochemistry & Molecular Biology

Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications

HT Lynch et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2006)