Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 27, Pages 8360-8363Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b04414
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Funding
- National Natural Science Foundation of China [21232003, 21472057, 21572074]
- [201422]
- [CCNU15A02007]
- [2015CFA033]
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The first copper-catalyzed asymmetric decarboxylative [4 + 1] cycloaddition of propargylic carbamates and sulfur ylides was successfully developed. This strategy led to a series of chiral indolines with synthetically flexible alkyne groups in good yields and with high enantio- and diastereoselectivities (up to 99% yield, 98% ee, and >95:5 dr). A possible mechanism and stereoinduction mode with copper-allenylidenes were proposed as the possible dipolar intermediate.
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