CX3CR1+ Alveolar Macrophages: A New Player in Lung Eosinophil Homeostasis

Article Biochemistry & Molecular Biology

Profibrotic properties of C1q+ interstitial macrophages in silica-induced pulmonary fibrosis in mice

Tatsuro Ogawa et al.

Summary: This study revealed the role of interstitial macrophages (IMs) in pulmonary fibrosis (PF) and their potential as a therapeutic target. IMs were found to have pro-fibrotic and anti-inflammatory properties in the fibrotic lungs. Depletion of C1q(+) IMs reduced activated fibroblasts and epithelial cells but worsened bodyweight loss and neutrophil infiltration in the silica-induced PF mouse model.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Review Immunology

Biology of lung macrophages in health and disease

Helena Aegerter et al.

Summary: This article describes how single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics can be used to separate and study different subpopulations of lung macrophages, as well as their importance and complexity in lung homeostasis and disease. It also discusses how lung macrophages undergo functional changes in different tissue states.

IMMUNITY (2022)

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Article Immunology

Differential regulation of Type 1 and Type 2 mouse eosinophil activation by apoptotic cells

Avishay Dolitzky et al.

Summary: This study demonstrates that eosinophils can interact with apoptotic cells, leading to polarized activation towards an anti-inflammatory phenotype. Apoptotic cells suppress the inflammatory responses of eosinophils and enhance the activation induced by specific cytokines. These findings reveal the heterogeneity of eosinophil activation patterns and highlight the potential role of apoptotic cells in regulating eosinophil polarization.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation

Maria Faas et al.

Summary: Uncoupling protein-2 and the transcription factor GATA3 were found to regulate the differentiation of AAMs in response to IL-33, leading to their polarization. IL-33 induced metabolic rewiring in macrophages, which subsequently triggered GATA3-mediated AAM polarization.

IMMUNITY (2021)

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Article Multidisciplinary Sciences