Related references
Note: Only part of the references are listed.
Article
Infectious Diseases
Sonja H. Brunvoll et al.
Summary: This study aimed to describe the post-acute sequelae of SARS-CoV-2 infection (PASC) related symptoms 3-15 months after a positive test in unvaccinated and vaccinated participants. The results showed no significant differences in PASC symptoms between vaccinated and unvaccinated participants, but vaccinated participants reported fewer memory problems compared to unvaccinated participants.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Microbiology
Hannah E. Davis et al.
Summary: Long COVID is a common and debilitating illness that affects at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, with a wide range of symptoms and impacts on multiple organ systems. There are an estimated 65 million individuals worldwide with long COVID, and the number of cases is increasing daily. Current diagnostic and treatment options are insufficient, and there is a need for clinical trials to address leading hypotheses. Future research should account for biases and testing issues, build on viral-onset research, include marginalized populations, and meaningfully engage patients.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Laorden et al.
RESPIRATORY MEDICINE
(2023)
Review
Gastroenterology & Hepatology
J. Thomas Gebert et al.
Summary: Viruses are common enteric pathogens, and human intestinal organoids (HIOs) are becoming increasingly popular in virology research. HIOs offer a more accurate representation of native tissue infection than traditional cell lines and animal models, and provide higher throughput. This review discusses recent advances in virology achieved through the use of HIOs, including cultivation of previously uncultivatable viruses, insights into tropism, entry, replication kinetics, and host-pathogen interactions. The speed and flexibility of HIO-based studies have also contributed to our knowledge of SARS-CoV-2 and antiviral therapeutics. Limitations of HIOs and future directions are also discussed.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yapeng Su et al.
Summary: Post-acute sequelae of COVID-19 (PASC) is an emerging global crisis, and the quantifiable risk factors and biological associations are not well understood. In this study, a deep multi-omic investigation was conducted on 309 COVID-19 patients, and four PASC-anticipating risk factors were identified at the time of initial diagnosis. The study also observed changes in immune states during recovery from COVID-19.
Article
Gastroenterology & Hepatology
Harsh K. Patel et al.
Summary: This study examined the association between gastrointestinal symptoms at initial presentation and clinical outcomes in hospitalized COVID-19 patients. The results showed that around 41% of the patients had gastrointestinal symptoms at initial presentation, but these symptoms were not associated with in-hospital all-cause mortality.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Qin Liu et al.
Summary: This study investigated the link between gut microbiome composition and post-acute COVID-19 syndrome. The results showed that the gut microbiome of patients with long-term complications of COVID-19 differed significantly from that of non-COVID-19 controls and patients without post-acute COVID-19 syndrome.
Article
Virology
Emma S. Winkler et al.
Summary: The study developed a mouse model for SARS-CoV-2 infection by introducing the human ACE2 gene into the mouse genome, providing insights into viral replication and pathology in mice. Additionally, the study identified the impact of the N501Y mutation in mice on viral replication and pathogenesis.
JOURNAL OF VIROLOGY
(2022)
Article
Medicine, General & Internal
Yan Xie et al.
Summary: This study finds that survivors of the acute phase of COVID-19 are at increased risk of developing various mental health disorders, including anxiety disorders, depressive disorders, and stress and adjustment disorders. The risk is even higher among those who were hospitalized or used medication. Therefore, addressing and prioritizing the mental health issues of COVID-19 survivors are crucial.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Kumar Vishven Naveen et al.
Summary: Fungal infection is a serious issue for immunocompromised and COVID-19 patients, leading to higher disease severity and mortality rates. Simultaneous fungal coinfection with COVID-19 can result in cytokine storms. SARS-CoV-2 infection disrupts the gut microbiota, and current treatments are facing challenges due to fungal resistance.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Microbiology
Lisa M. Olsson et al.
Summary: The composition and function of the gut microbiota vary significantly between individuals, and this variation can potentially be explained by intra-individual dynamics. The abundance of Faecalibacterium prausnitzii and Bifidobacterium species is negatively associated with the stability of the gut microbiota composition. In contrast, facultative anaerobes and aerotolerant bacteria, such as Escherichia coli and Lactobacillus acidophilus, show extensive variation independent of compositional stability. The contribution of intra-individual variance to the total variance is greater for functional pathways than for microbial species. Therefore, reliable quantification of microbial features requires repeated sampling to address intra-individual variations of the gut microbiota.
CELL HOST & MICROBE
(2022)
Review
Immunology
John W. Bostick et al.
Summary: The intestinal microbiome influences neuroinflammatory diseases through multiple communication pathways with the brain, involving the production of metabolites, modulation of inflammatory tone, and affecting immune cell trafficking.
CURRENT OPINION IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Jin H. Han et al.
Summary: Persistent symptoms of COVID-19 are associated with poorer long-term health status, lower quality of life, and higher psychological distress in patients with mild acute COVID-19.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2022)
Review
Clinical Neurology
Lavienraj Premraj et al.
Summary: Neurological and neuropsychiatric symptoms that persist or develop three months after the onset of COVID-19 pose a significant threat to the global healthcare system. A systematic review analyzed data from multiple studies and found that fatigue, cognitive dysfunction, and sleep disturbances were key features of post-COVID-19 syndrome. Psychiatric manifestations such as anxiety and depression were also common and increased in prevalence over time.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Editorial Material
Immunology
Michael J. J. Peluso et al.
Summary: Intense investigation is being carried out to understand the predictors and determinants of post-acute sequelae of SARS-CoV-2 infection (PASC), including 'long COVID'. Recent studies provide clues to the mechanisms behind this condition, aiming to identify host or virus factors that can be intervened upon to prevent or reverse PASC.
TRENDS IN IMMUNOLOGY
(2022)
Review
Virology
Tsung-Hsien Chen et al.
Summary: SARS-CoV-2 has evolved into a virus that primarily results in mild or asymptomatic disease, making its transmission more challenging to control. In addition to the respiratory tract, SARS-CoV-2 also infects the digestive tract. Gastrointestinal symptoms may occur with or before respiratory symptoms in patients with COVID-19. The gastrointestinal microbiome may play a role in determining the risk of SARS-CoV-2 infection and disease severity. Therefore, the development of oral vaccines and maintaining intestinal microbiota profiles could contribute to early control of COVID-19 outbreaks.
Article
Geriatrics & Gerontology
Panyuan Guo et al.
Summary: Since its emergence in December 2019, COVID-19 has become a global pandemic caused by SARS-CoV-2. Many COVID-19 patients experience neurological symptoms, and there is evidence of neural damage in some individuals. COVID-19 infection can lead to structural and functional changes in the brain, resulting in cognitive problems. This study aims to understand the cognitive problems in Long COVID, and found that the severity of initial illness is a significant predictor of ongoing symptoms. Additionally, certain symptoms during the initial illness are more common in individuals with more severe ongoing symptoms.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Kyung Ku Jang et al.
Summary: In this study, researchers used intestinal organoid-derived cultures to investigate the variability in gastrointestinal effects associated with COVID-19. They found that the replication of SARS-CoV-2 in small intestinal and colonic organoids varied significantly between different donors. The susceptibility to infection was correlated with ACE2 expression levels and independent of demographic or clinical features. The study also revealed a delayed but robust interferon response in organoid-derived cultures, with the magnitude of the response corresponding to the degree of SARS-CoV-2 infection. Interestingly, the Omicron variant spike protein showed increased infectivity in the organoids, suggesting a higher tropism for intestinal tissue.
Article
Immunology
Sokratis N. Zisis et al.
Summary: This study suggests that COVID-19 vaccine is protective against mortality and each incident postacute sequelae of coronavirus disease 2019 (PASC) outcome. In addition, vaccination is associated with a significantly lower likelihood of experiencing new or persistent PASC symptoms.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Anthony Fernandez-Castaneda et al.
Summary: COVID survivors may experience lingering neurological symptoms similar to cognitive impairment related to cancer therapy. Research has found that respiratory SARS-CoV-2 infection can cause white-matter-selective microglial reactivity and affect neurogenesis and CCL11 levels.
Article
Cell Biology
Nicole Sarden et al.
Summary: Through studying severe SARS-CoV-2 infection, influenza A viral pneumonia, and systemic corticosteroid use, we found a crucial coupling between innate B1a lymphocytes, Af-binding natural immunoglobulin G antibodies, and lung neutrophils. Failure of this axis allows rapid fungal invasion and disease, but reestablishing it with immunoglobulin therapy can restore resistance.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Medicine, General & Internal
Shirley Sylvester et al.
Summary: This study conducted literature reviews and found differential effects of sex on sequelae from COVID-19 and long COVID syndrome. Few studies reported sex-disaggregated data for COVID-19, highlighting the need for further sex-based research and reporting.
CURRENT MEDICAL RESEARCH AND OPINION
(2022)
Article
Multidisciplinary Sciences
Manish Boolchandani et al.
Summary: International travel contributes to the global spread of antimicrobial resistance, and travelers' diarrhea increases the risk of acquiring multidrug-resistant organisms. This study found that diarrhea disrupts the stability of gut microbiome and leads to an increased abundance of antimicrobial resistance genes. The study also identified bacterial taxa that differ between diarrhea and non-diarrhea samples.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Qin Liu et al.
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Mojca Jensterle et al.
Summary: The article reviews the rationale for glucocorticoid use in COVID-19 and emphasizes the need to be cautious about glucocorticoid-induced adrenal insufficiency. The authors also discuss other mechanisms that may affect HPA axis function and the increased risk and severity of COVID-19 in patients with pre-existing HPA axis disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Emily E. Chasco et al.
Summary: This study aimed to better understand the experiences of patients with Post-acute sequelae of SARS-CoV-2 (PASC), focusing on the impact of cognitive complaints (brain fog) and fatigue on daily activities, work/employment, and interpersonal relationships. Through qualitative interviews, the study revealed that fatigue and brain fog negatively affected all domains, including work, support, personal relationships. Additionally, social stigma significantly impacted the emotional and mental health of the patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Ram Prasad et al.
Summary: This study aimed to investigate whether plasma analysis could provide insight into gut barrier dysfunction in patients with COVID-19 infection. The findings showed significant dysbiosis of the plasma microbiome in COVID-19 patients, along with increased abundance of Actinobacteria species and decreased abundance of Bacteroides species. Moreover, the concentration of gut permeability markers was significantly elevated in COVID-19 patients compared to healthy individuals. These findings suggest that the gut may contribute to worsening COVID-19 outcomes and targeting the gut could be a potential strategy for improving patient outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Daniel E. Freedberg et al.
Summary: A large number of COVID-19 patients experience persistent gastrointestinal symptoms, with half of them experiencing these symptoms during the acute phase and 10-25% still experiencing them 6 months after recovery. These symptoms are associated with mental health symptoms, such as anxiety and depression, that predate COVID-19 or occur concurrently after recovery. The causes of these symptoms are still unknown, but possibilities include the direct infection of the gastrointestinal tract by the SARS-CoV-2 virus, changes in the gut microbiome, systemic inflammation, critical illness, and the effects of pandemic stress on gastrointestinal function and symptom perception.
CURRENT OPINION IN GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Lucie Bernard-Raichon et al.
Summary: The authors demonstrate that SARS-CoV-2 infection causes dysbiosis in the gut microbiome and alterations in gut epithelial cells in a mouse model. They also correlate the observed dysbiosis in COVID-19 patients with bloodstream infections by matching bacterial sequences from stool samples to organisms found in the blood. This study provides evidence that dysbiosis in the gut microbiome is associated with translocation of bacteria into the blood during COVID-19, leading to life-threatening secondary infections.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Matthew R. Stutz et al.
Summary: This study demonstrates that the composition of fecal microbiota and the concentrations of microbiota-derived metabolites can predict the trajectory of respiratory function and death in patients with severe SARS-Cov-2 infection, highlighting the importance of the gut-lung axis in the recovery from COVID-19.
NATURE COMMUNICATIONS
(2022)
Review
Microbiology
Ethan B. Jansen et al.
Summary: This article introduces the clinical aspects of COVID-19 and Long COVID (PASC) caused by Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) in humans and animals. It explores possible mechanisms and treatments for the diseases.
Article
Microbiology
Xiaomin Cheng et al.
Summary: This study conducted a meta-analysis to investigate the alterations in gut microbiota of COVID-19 patients across different populations. The results showed consistent decrease in gut bacterial diversity in both acute and recovery phases of COVID-19. Additionally, there was a depletion of anti-inflammatory bacteria and enrichment of pro-inflammatory taxa in COVID-19 patients during the acute phase. Furthermore, the gut microbiota of COVID-19 recovered patients remained in unhealthy ecostates. These findings provide insights into the gut microbial perturbations associated with COVID-19 and suggest potential biomarkers for microbiome-based diagnostics and therapeutics.
Review
Gastroenterology & Hepatology
Arup Choudhury et al.
Summary: This study conducted a systematic review and meta-analysis to investigate the frequency of gastrointestinal (GI) manifestations in long COVID patients. The results showed that 12% of patients after COVID-19 and 22% of long COVID patients experienced GI symptoms. The most common GI symptoms in long COVID were loss of appetite, dyspepsia, irritable bowel syndrome, loss of taste, and abdominal pain. The study's limitations include significant heterogeneity and a small number of included studies.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Article
Medicine, Research & Experimental
Aravind Natarajan et al.
Summary: This study found that SARS-CoV-2 viral RNA can persist in feces for up to 7 months in individuals with mild to moderate COVID-19. Furthermore, patients with gastrointestinal symptoms are more likely to shed viral RNA in their feces.
Article
Immunology
Ciara E. Keogh et al.
Summary: Research suggests that neonatal antibiotic use may lead to gut dysbiosis, affecting myelination, behavior, and cognitive function in the long term.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Gastroenterology & Hepatology
Yun Kit Yeoh et al.
Summary: This study found that the gut microbiome composition was significantly altered in patients with COVID-19 compared to non-COVID-19 individuals, regardless of medication received. Certain gut commensals known for their immunomodulatory potential were underrepresented in patients and remained low even after disease resolution. Additionally, the altered gut microbiome composition correlated with disease severity and elevated levels of inflammatory cytokines and blood markers.
Article
Multidisciplinary Sciences
Giovanni Giuseppe Giobbe et al.
Summary: COVID-19 typically presents as a respiratory illness, but clinical reports have described gastrointestinal symptoms. Researchers generated gastric organoids from human biopsies and found that the virus can efficiently infect gastric epithelium, suggesting that the stomach might play an active role in fecal-oral transmission of SARS-CoV-2.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Josefine Roswall et al.
Summary: The gut microbiota is established by four different colonization patterns, with some late colonizers correlating with increased diversity. Children show individual dynamics in the development trajectory of the gut microbiota.
CELL HOST & MICROBE
(2021)
Article
Gastroenterology & Hepatology
Markus F. Neurath et al.
Article
Microbiology
Tao Zuo et al.
Summary: Patients with COVID-19 exhibited distinctive gut virome composition compared to non-COVID-19 subjects, which persisted even after the resolution of the disease. The findings suggest that the gut virome may play a role in modulating host immunity and impacting the severity of SARS-CoV-2 infection.
Article
Immunology
Carly Hennessey et al.
Summary: Early-life infection with EPEC can lead to intestinal inflammation, cognitive impairments, increased neurogenesis, and neuroinflammation in adulthood. Adult mice show changes in intestinal physiology, intestinal inflammation, and dysbiosis of the gut microbiota due to neonatal EPEC infection.
INFECTION AND IMMUNITY
(2021)
Article
Medicine, Research & Experimental
John P. Haran et al.
Summary: In a study, it was found that patients with long COVID had higher abundance of bacteria in the oral microbiome that can induce inflammation, such as Prevotella and Veillonella genera. These microbes may be related to the development of ongoing symptoms in patients, and the oral microbiome of long COVID patients resembled that of patients with chronic fatigue syndrome.
Article
Gastroenterology & Hepatology
Jiabao Cao et al.
Summary: Research shows that COVID-19 patients have distinct gut virome and bacteriome compared to healthy individuals, with a bacterial dysbiosis signature. Differences in bacterial/viral compositions were observed in patients of different severities, with severe cases having more opportunistic pathogens and fewer butyrate-producing bacteria.
Article
Biochemistry & Molecular Biology
Markus Hoffmann et al.
Article
Multidisciplinary Sciences
Mart M. Lamers et al.
Article
Gastroenterology & Hepatology
Eloisa Salvo et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2020)
Article
Gastroenterology & Hepatology
Tao Zuo et al.
Article
Immunology
Emma S. Winkler et al.
Review
Physiology
John F. Cryan et al.
PHYSIOLOGICAL REVIEWS
(2019)
Review
Allergy
Sandy R. Durrani et al.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2018)
Review
Microbiology
Kurtis F. Budden et al.
NATURE REVIEWS MICROBIOLOGY
(2017)
Letter
Neurosciences
Ebere S. Ogbonnaya et al.
BIOLOGICAL PSYCHIATRY
(2015)
Article
Neurosciences
Daniel Erny et al.
NATURE NEUROSCIENCE
(2015)
Review
Microbiology
Linh D. N. Nguyen et al.
FRONTIERS IN MICROBIOLOGY
(2015)
Article
Multidisciplinary Sciences
Jeremiah J. Faith et al.
Article
Gastroenterology & Hepatology
Melanie G. Gareau et al.
Article
Multidisciplinary Sciences
Saul A. Villeda et al.
Article
Multidisciplinary Sciences
Rochellys Diaz Heijtza et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
Article
Behavioral Sciences
F. Tanriverdi et al.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2007)
