Using SARS-CoV-2 Antibody Testing in COVID-19 Research

Article Medicine, General & Internal

Physical Activity, Sedentary Behavior, and Risk of Coronavirus Disease 2019

Wenjie Ma et al.

Summary: According to data from the Nurses' Health Study II and Health Professionals Follow-Up Study, there is a correlation between prepandemic physical activity and lower risk and severity of SARS-CoV-2 infection and COVID-19. Longer periods of sedentary behavior are also associated with lower risk of infection.

AMERICAN JOURNAL OF MEDICINE (2023)

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Letter Medicine, General & Internal

Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection

Sebastian Havervall et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Immunology

Pre-Existing Comorbidities Diminish the Likelihood of Seropositivity after SARS-CoV-2 Vaccination

Alok R. Amraotkar et al.

Summary: The presence of chronic health conditions, especially chronic kidney disease and autoimmune disease, increases the likelihood of seronegative status among individuals who are fully vaccinated to SARS-CoV-2. The absence of any chronic health conditions is protective and increases the likelihood of a positive serological response. The risk of seronegative status increases with an increase in the number of comorbidities and the use of CHC-related medications.

VACCINES (2022)

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Article Cell Biology

IgA dominates the early neutralizing antibody response to SARS-CoV-2

Delphine Sterlin et al.

Summary: The study found that humoral immune responses to SARS-CoV-2 infection are dominated by IgA antibodies, with specific IgA plasmablasts rapidly expanding shortly after symptom onset and peaking in the third week of the disease. Virus-specific antibody responses include IgG, IgM, and IgA, with IgA playing a greater role in virus neutralization compared to IgG.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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News Item Medicine, General & Internal

The Flawed Science of Antibody Testing for SARS-CoV-2 Immunity

Jennifer Abbasi

Summary: Experts recommend against using antibody testing to assess protection from SARS-CoV-2 post-vaccination or infection.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Multidisciplinary Sciences

Serological assessment of SARS-CoV-2 infection during the first wave of the pandemic in Louisville Kentucky

Krystal T. Hamorsky et al.

Summary: Serological assays are crucial for managing the COVID-19 pandemic, with ELISA methods showing accuracy in measuring antibody responses. The developed ELISA method demonstrated positive correlation with neutralization assays, indicating broad immune responses among individuals.

SCIENTIFIC REPORTS (2021)

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Article Virology