Extranodal natural killer/T-cell lymphoma nasal type in a western population: Molecular profiling identifies new therapeutic targets

(A) Correlation matrix of unsupervised co-regulated genes, based on the 208 genes included in the NanoString platform. Some of the clusters of co-regulated genes corresponded to the following: Inflammatory cells; Epstein-Barr virus; B-cells; Cytotoxic T-cells; T-cells; and Proliferation. (B) Analysis of genomic alterations by targeted sequencing. Distribution of mutations in the 62 analyzed genes. Rows correspond to sequenced genes, columns represent individual patients. Color coding: green, missense; blue, synonymous; pink, frameshift; violet, Indel; red, stop gained; yellow, UTR.

Automated summary

This study used the NanoString platform to analyze the correlation matrix of unsupervised co-regulated genes, which included 208 genes. Several clusters of co-regulated genes were found to be associated with inflammatory cells, Epstein-Barr virus, B-cells, cytotoxic T-cells, T-cells, and proliferation. Additionally, the genomic alterations in 62 analyzed genes were investigated using targeted sequencing and different types of mutations were identified.