Journal
AMERICAN JOURNAL OF GASTROENTEROLOGY
Volume 118, Issue 9, Pages 1693-1697Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.14309/ajg.0000000000002337
Keywords
IBD; adverse events; SARS-CoV-2; serology
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SARS-CoV-2 vaccines are safe for patients with IBD, with no cases of IBD flare observed. Injection site reactions after the fourth dose may indicate increased antibody levels.
INTRODUCTION:We determined adverse events after 4 doses of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccine in those with inflammatory bowel disease (IBD), associations between antibodies and injection site reactions (ISR), and risk of IBD flare.METHODS:Individuals with IBD were interviewed for adverse events to SARS-CoV-2 vaccine. Multivariable linear regression assessed the association between antibody titers and ISR.RESULTS:Severe adverse events occurred in 0.03%. ISR were significantly associated with antibody levels after the fourth dose (geometric mean ratio = 2.56; 95% confidence interval 1.18-5.57). No cases of IBD flare occurred.DISCUSSION:SARS-CoV-2 vaccines are safe for those with IBD. ISR after the fourth dose may indicate increased antibodies.
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