Establishing dietary reference intakes and laboratory reference ranges for folate-maybe not so simple for infants

Article Nutrition & Dietetics

Infant blood concentrations of folate markers and catabolites are modified by 5,10-methylenetetrahydrofolate reductase C677T genotype and dietary folate source

Rima Obeid et al.

Summary: This study investigated the association between infant's MTHFR C677T genotype, the dietary folate source, and concentrations of folate markers in the blood. The results showed that the use of infant formula with 5-MTHF increased the concentrations of RBC folate and plasma pABG in infants. Over time, the plasma concentrations of 5-MTHF and pABG also significantly increased in breastfed infants. However, carriers of the TT genotype still had lower pABG concentrations compared to carriers of the CC genotype, and it is unclear whether these differences have any clinical relevance.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2023)

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Article Public, Environmental & Occupational Health

Preventing birth defects, saving lives, and promoting health equity: an urgent call to action for universal mandatory food fortification with folic acid

Vijaya Kancherla et al.

Summary: Mandatory fortification with folic acid is a safe and effective intervention to prevent spina bifida and anencephaly, but its implementation is limited globally. Urgent action is needed to pass a resolution for universal mandatory fortification to accelerate prevention efforts and achieve the Sustainable Development Goals by 2030.

LANCET GLOBAL HEALTH (2022)

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Article Nutrition & Dietetics

Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop

Padma Maruvada et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2020)

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Article Nutrition & Dietetics

Periconceptional intake of folic acid among low-risk women in Canada: summary of a workshop aiming to align prenatal folic acid supplement composition with current expert guidelines

Yvonne Lamers et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2018)

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Article Nutrition & Dietetics

Total folate and unmetabolized folic acid in the breast milk of a cross-section of Canadian women

Rachael Page et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2017)

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Article Nutrition & Dietetics

High concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood

Lesley Plumptre et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2015)

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Establishing dietary reference intakes and laboratory reference ranges for folate-maybe not so simple for infants

Related references

Infant blood concentrations of folate markers and catabolites are modified by 5,10-methylenetetrahydrofolate reductase C677T genotype and dietary folate source

Preventing birth defects, saving lives, and promoting health equity: an urgent call to action for universal mandatory food fortification with folic acid

Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop

Periconceptional intake of folic acid among low-risk women in Canada: summary of a workshop aiming to align prenatal folic acid supplement composition with current expert guidelines

Total folate and unmetabolized folic acid in the breast milk of a cross-section of Canadian women

High concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood

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