Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 24, Pages 7492-7495Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b03760
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Funding
- National Insitutes of Health [R01GM111480]
- Alfred P. Sloan Fellowship
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Iron-catalyzed cross-couplings with simple ferric salts have been known since the 1970s, pioneered by Kochi for cross-coupling using alkylmagnesium nucleophiles including MeMgBr. While Kochi observed the formation of a S = 1/2 iron species in reactions of simple ferric salts with MeMgBr proposed to be an iron(I) species, the identity of this species has remained undefined for nearly 40 years. Herein, we report the isolation and characterization of [MgCl(THF)(5)] [Fe8Me12], which combined with EPR and MCD studies is shown to be consistent with Kochi's S = 1/2 species. Reaction studies with beta-bromostyrene demonstrate that this species alone displays minimal reactivity but, when combined with additional MeMgBr, leads to rapid and selective formation of cross-coupled product.
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