Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 41, Pages 13493-13496Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b08114
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Funding
- Chinese Academy of Sciences by the Strategic Priority Research Program [XDB20020200, QYZDJ-SSW-SLH029]
- National Natural Science Foundation of China [21132008]
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The combination of Cu(acac)(2) and N,N'-bis(4-hydroxyl-2,6-dimethylphenyl)oxalamide (BHMPO) provides a powerful catalytic system for hydroxylation of (hetero)aryl halides. A wide range of (hetero)aryl chlorides bearing either electron-donating or-withdrawing groups proceeded well at 130 degrees C, delivering the corresponding phenols and hydroxylated heteroarenes in good to excellent yields. When more reactive (hetero)aryl bromides and iodides were employed, the hydroxylation reactions completed at relatively low temperatures (80 and 60 degrees C, respectively) at low catalytic loadings (0.5 mol % Cu).
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