☆ 4.6 Article

Dupilumab but not cyclosporine treatment shifts the microbiome toward a healthy skin flora in patients with moderate-to-severe atopic dermatitis

ALLERGY (2023)

Related references

Note: Only part of the references are listed.

Article Allergy

Blood transcriptome profiling identifies 2 candidate endotypes of atopic dermatitis

Lena Moebus et al.

Summary: This study explored the blood transcriptomic features of moderate to severe atopic dermatitis (AD). The results showed that AD patients exhibited pronounced inflammatory expression signatures and could be stratified into eosinophilic and noneosinophilic endotypes. Additionally, treatment strategies for the eosinophil-high endotype may require more attention to the restoration of natural killer cell function.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Add to Collection

Article Dermatology

Infections in children and adolescents treated with dupilumab in pediatric clinical trials for atopic dermatitis-A pooled analysis of trial data

Amy S. Paller et al.

Summary: The study findings indicate that dupilumab treatment in children and adolescents with AD does not increase overall infection risk and is associated with lower rates of skin infections compared to placebo.

PEDIATRIC DERMATOLOGY (2022)

Add to Collection

Review Allergy

The HOME Core outcome set for clinical trials of atopic dermatitis

Hywel C. Williams et al.

Summary: Core outcome sets are crucial in atopic dermatitis research, providing a standardized approach to measuring outcomes and improving clinical practice.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Add to Collection

Article Allergy

Dupilumab significantly improves skin barrier function in patients with moderate-to-severe atopic dermatitis

Evgeny Berdyshev et al.

Summary: Inhibition of IL-4/IL-13 signaling by dupilumab allows restoration of skin lipid composition and barrier function in patients with moderate-to-severe AD. Treatment with dupilumab significantly decreased TEWL in AD lesions, normalized lipid composition, and increased ceramide chain length in lesional and non-lesional stratum corneum of AD patients, achieving a full response after 8 weeks of treatment.

ALLERGY (2022)

Add to Collection

Letter Dermatology

Real-world data on the effectiveness, safety and drug survival of dupilumab: an analysis from the TREATgermany registry

Dora Stoelzl et al.

BRITISH JOURNAL OF DERMATOLOGY (2022)

Add to Collection

Article Dermatology

Uptake of Staphylococcus aureus by keratinocytes is reduced by interferon-fibronectin pathway and filaggrin expression

Ryu Miyake et al.

Summary: The study found that Staphylococcus aureus strains from atopic dermatitis patients are more easily internalized by keratinocytes, with internalization largely mediated by the IFN-gamma-fibronectin pathway and partially regulated by filaggrin expression.

JOURNAL OF DERMATOLOGY (2022)

Add to Collection

Article Allergy

Blood transcriptome profiling identifies 2 candidate endotypes of atopic dermatitis

Lena Moebus et al.

Summary: This study identified blood transcriptomic features of moderate to severe AD patients, stratifying them into eosinophilic and noneosinophilic endotypes. Patients of different endotypes exhibited significant differences in gene expression and clinical manifestations, which may be crucial for designing stratified trial designs and treatment strategies.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

Add to Collection

Review Allergy

Efficacy and safety of dupilumab for moderate-to-severe atopic dermatitis: A systematic review for the EAACI biologicals guidelines

Ioana Agache et al.

Summary: This review evaluated the efficacy, safety, and economic impact of dupilumab compared to standard care for uncontrolled moderate-to-severe atopic dermatitis. Dupilumab showed significant improvements in symptoms and quality of life for both adult and adolescent patients. Long-term safety data is needed for both children and adults, along with more efficacy data for the pediatric population.

ALLERGY (2021)

Add to Collection

Article Allergy

TH cell diversity and response to dupilumab in patients with atopic dermatitis

Coline Trichot et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Add to Collection

Article Allergy

Atopic dermatitis displays stable and dynamic skin transcriptome signatures

Lena Mobus et al.

Summary: Skin transcriptome studies in atopic dermatitis have shown core features of disturbed epidermal differentiation and IL-31/IL-1 signaling activation, along with type 2 inflammation, T(H)17 signaling, and natural killer cell function. IL4RA is a key dysregulated gene, and cyclosporine and dupilumab have distinct effects on the transcriptome in AD patients.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Add to Collection

Article Allergy

Staphylococcus epidermidis protease EcpA can be a deleterious component of the skin microbiome in atopic dermatitis

Laura Cau et al.

Summary: Staphylococcus epidermidis may damage the skin by producing a protease, EcpA, which degrades barrier proteins and induces inflammation. The abundance of S epidermidis and expression of ecpA mRNA on the skin of some atopic patients may be related to disease severity, while another commensal bacterium, Staphylococcus hominis, can inhibit EcpA production.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Add to Collection

Article Allergy

Staphylococcus aureus second immunoglobulin-binding protein drives atopic dermatitis via IL-33

Arwa Al Kindi et al.

Summary: The study identified Sbi as a key virulence factor derived from Staphylococcus aureus, capable of inducing the release of IL-33 from human keratinocytes to promote type 2 immune responses underlying atopic dermatitis. This study sheds light on the mechanism of how S. aureus drives allergic pathology in AD patients in the absence of infection.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Add to Collection

Letter Allergy

Dupilumab reduces inflammation and restores the skin barrier in patients with atopic dermatitis

Maria Helena Rohner et al.

ALLERGY (2021)

Add to Collection

Article Allergy

Elevated NK-cell transcriptional signature and dysbalance of resting and activated NK cells in atopic dermatitis

Lena Moebus et al.

Summary: The skin of patients with AD shows dysregulation of NK cells, which is only partially reversed despite clinical improvement under systemic therapy. This may represent a yet underappreciated disease mechanism.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Add to Collection

Review Immunology

Mechanisms for control of skin immune function by the microbiome

Teruaki Nakatsuji et al.

Summary: The skin serves as the largest area for direct contact between microbes and host immunocytes, allowing constant communication between the host and the diverse microbial community. Coagulase-negative staphylococci, abundant on human skin, are regulated through various mechanisms and certain species produce products that enhance host immunity. This emerging concept of bacteriotherapy is defining mechanisms of action and highlighting the importance of the microbiome for immune homeostasis.

CURRENT OPINION IN IMMUNOLOGY (2021)

Add to Collection

Review Allergy

Association between barrier impairment and skin microbiota in atopic dermatitis from a global perspective: Unmet needs and open questions

Razvigor Darlenski et al.

Summary: Atopic diathesis is a prevalent condition with a wide range of clinical manifestations and age of onset, characterized by a common inherited epidermal barrier dysfunction. Microbiome diversity and contact with nonpathogenic microbes play a key role in immune system maturation and may impact the development of the disease.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Add to Collection

Article Dermatology

Host traits, lifestyle and environment are associated with human skin bacteria

L. Moitinho-Silva et al.

Summary: This study found associations of skin microbiota with skin microenvironment, age, body mass index, sex, dietary macronutrients, smoking, alcohol consumption, skin pH, skin type, transepidermal water loss, education and environmental exposures. The skin bacterial community is shaped by the skin microenvironment and host physiology to a greater extent than single skin physiological feature, lifestyle, and environmental exposure.

BRITISH JOURNAL OF DERMATOLOGY (2021)

Add to Collection

Article Microbiology

Microbiota regulate innate immune signaling and protective immunity against cancer

Changsheng Xing et al.

Summary: The research revealed that mice lacking the immune signaling molecule TAK1 exhibited complete resistance to colitis and CRC through microbiome alterations. The altered microbiota in Tak1(Delta M/Delta M) mice promote IL-1 beta and IL-6 signaling pathways, which are necessary for inducing protective intestinal Th17 cells.

CELL HOST & MICROBE (2021)

Add to Collection

Article Microbiology

Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor

Aayushi Uberoi et al.

Summary: This research demonstrates the essential role of the skin microbiome in regulating skin barrier formation and repair, mediated by microbiota signaling through the aryl hydrocarbon receptor (AHR) in keratinocytes. These findings reveal a fundamental mechanism whereby the microbiota influences the integrity of the skin barrier.

CELL HOST & MICROBE (2021)

Add to Collection

Article Dermatology

IL-4R alpha Blockade by Dupilumab Decreases Staphylococcus aureus Colonization and Increases Microbial Diversity in Atopic Dermatitis

Chris Callewaert et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

Add to Collection

Article Dermatology

Baseline characteristics, disease severity and treatment history of patients with atopic dermatitis included in the German AD Registry TREATgermany

A. Heratizadeh et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Add to Collection

Editorial Material Dermatology

Targeting T2 Inflammation by Dupilumab Impacts on the Microbiomic Menage a Trois of Atopic Dermatitis

Thomas Bieber

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

Add to Collection

Article Allergy

Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis

Emma Guttman-Yassky et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Add to Collection

Article Dermatology

Infections in Dupilumab Clinical Trials in Atopic Dermatitis: A Comprehensive Pooled Analysis

Lawrence F. Eichenfield et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2019)

Add to Collection

Article Biotechnology & Applied Microbiology

Role and plasticity of Th1 and Th17 responses in immunity to Staphylococcus aureus

Alessandra Ferraro et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2019)

Add to Collection

Article Allergy

The microbiome in patients with atopic dermatitis

Amy S. Paller et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Add to Collection

Article Multidisciplinary Sciences

Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

V. Gopalakrishnan et al.

SCIENCE (2018)

Add to Collection

Article Allergy

Epidermal lipid composition, barrier integrity, and eczematous inflammation are associated with skin microbiome configuration

Hansjorg Baurecht et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Add to Collection

Article Dermatology

Risk of infection in patients with atopic dermatitis treated with dupilumab: A meta-analysis of randomized controlled trials

Patrick Fleming et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship

Joan A. Geoghegan et al.

TRENDS IN MICROBIOLOGY (2018)

Add to Collection

Review Multidisciplinary Sciences

Skin microbiota-host interactions

Y. Erin Chen et al.

NATURE (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance

Stephan P. Rosshart et al.

CELL (2017)

Add to Collection

Article Dermatology

Influence of Th2 Cytokines on the Cornified Envelope, Tight Junction Proteins, and β-Defensins in Filaggrin-Deficient Skin Equivalents

Stefan Hoenzke et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)

Add to Collection

Article Biochemical Research Methods

DADA2: High-resolution sample inference from Illumina amplicon data

Benjamin J. Callahan et al.

NATURE METHODS (2016)

Add to Collection

Article Immunology

Dysbiosis and Staphyloccus aureus Colonization Drives Inflammation in Atopic Dermatitis

Tetsuro Kobayashi et al.

IMMUNITY (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis

Heidi H. Kong et al.

GENOME RESEARCH (2012)

Add to Collection

Article Biotechnology & Applied Microbiology

Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy

Qiong Wang et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2007)

Add to Collection

Article Medicine, General & Internal

Endogenous antimicrobial peptides and skin infections in atopic dermatitis

PY Ong et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.