Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 9, Pages 2937-2940Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b13215
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Funding
- University of Texas at Austin
- Welch Foundation [F-1883]
- Banks Summer Fellowship from the UT Department of Chemistry
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We report a pair of fluorinated, redox-active copper complexes for potential use as F-19 MRI contrast agents for detecting cellular hypoxia. Trifluorinated Cu(II) ATSM-F-3 displays the appropriate redox potential for selective accumulation in hypoxic cells and a completely quenched F-19 NMR signal that is turned on following reduction to Cu(I). Incubation of cancer cells with CuATSM-F-3 resulted in a selective detection of F-19 signal in cells grown under hypoxic conditions.
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