Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 25, Pages 7824-7827Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b03384
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Funding
- NIH [GM-64451]
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Nickel-catalyzed enantioselective cross-couplings between symmetric cyclic sulfates and aromatic Grignard reagents are described. These reactions are effective with a broad range of substituted cyclic sulfates and deliver products with asymmetric tertiary carbon centers. Mechanistic experiments point to a stereoinvertive S(N)2-like oxidative addition of a nickel complex to the electrophilic substrate.
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