Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 8, Pages 2762-2768Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b12704
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Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canada Foundation for Innovation (CFI)
- University of Calgary
- Spanish Ministerio de Economia y Competitividad [CTQ2013-48767-C3-1-R]
- European Social Funds
- SUR del DEC de la Generalitat de Catalunya [2015 FI_B1 00063]
- Richard J. Schmeelk Foundation
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Herein, we synthesized a series of 10 core-shell silver-silica nanoparticles with a photosensitizes, Rose Bengal, tethered to their surface. Each nanoparticle possesses an identical silver core of about 67 nm, but presents a different silica shell thickness ranging from 5 to 100 am. These hybrid plasmonic nanoparticles thus afford a plasmonic nanostructure platform with a source,of singlet oxygen (O-1(2)) at a well-defined distance from the metallic core. Via time-resolved and steady state spectroscopic techniques, we demonstrate the sillier core exerts a= dual role of enhancing both the production of O-1(2), through enhanced absorption of light, and its radiative decay, which in turn boosts O-1(2) phosphorescence emission to a greater extent. Furthermore, we show both the production arid emission of O-1(2), in vitro to be dependent on proximity to the plasmonic nanostructure. Our results clearly exhibit three distinct regimes as the plasmonic nanostructure moves apart from the O-1(2) source, with a greater enhancement for silica shell thicknesses ranging between 10 and 20 nm. Moreover, these hybrid plasmonic nanoparticles can be delivered to both Gram-positive and Gram-negative bacteria boosting both photoantibacterial activity and detection limit of O-1(2) in cells.
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