Integrative exploration of the mutual gene signatures and immune microenvironment between benign prostate hyperplasia and castration-resistant prostate cancer

Article Biochemistry & Molecular Biology

The prolyl hydroxylase OGFOD1 promotes cancer cell proliferation by regulating the expression of cell cycle regulators

Toshiya Fujisaki et al.

Summary: OGFOD1 is an important factor that regulates the transcription and stabilization of cell cycle-related genes, and plays a role in maintaining the function of specific cell cycle regulators during cancer cell proliferation.

FEBS LETTERS (2023)

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Review Oncology

Managing Resistance to Immune Checkpoint Inhibitors in Lung Cancer: Treatment and Novel Strategies

Antonio Passaro et al.

Summary: A proportion of lung cancer patients can benefit from immune checkpoint inhibitors (ICIs), but most patients experience disease progression during or after treatment. Immune resistance has different definitions based on clinical and biological features. Combination therapies are being developed to delay or prevent resistance to ICIs.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Review Oncology

Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways

Lukas Kraehenbuehl et al.

Summary: The discovery and clinical implementation of immune-checkpoint inhibitors like CTLA4, PD-1, and PD-L1 have significantly improved outcomes for patients with advanced-stage cancers. However, a majority of patients do not respond to these agents, emphasizing the need for further research into alternative immunomodulatory pathways and targeting tumor metabolism to enhance treatment efficacy.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Article Cell Biology

Analyzing and validating the prognostic value and immune microenvironment of clear cell renal cell carcinoma

Jingwei Ke et al.

Summary: The tumor immune microenvironment (TIME) plays a crucial role in the diagnosis, treatment, and prognosis of clear cell renal cell carcinoma (ccRCC). Through clustering analysis, we identified immune subgroups and identified significant modules and hub genes associated with these subgroups. We also established a nomogram to predict the survival outcomes of ccRCC patients and identified LAG3 and GZMK as potential biomarkers for TIME.

ANIMAL CELLS AND SYSTEMS (2022)

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Editorial Material Oncology

Boosting anticancer immunotherapy through androgen receptor blockade

Laura Pala et al.

Summary: Androgen receptor negatively modulates CD8(+) T cell-driven antitumor immune response, and targeting the androgen-axis blockade may improve the activity of ICIs in CRPC.

CANCER CELL (2022)

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Review Immunology

Turning cold tumors hot: from molecular mechanisms to clinical applications

Jiahui Zhang et al.

Summary: Immune checkpoint blockade therapies have shown clinical benefit, but many immune-cold solid tumors do not respond. Understanding the mechanisms of cold to hot tumor transition and tumor immunotyping can provide insights for effective therapeutic strategies against cancer.

TRENDS IN IMMUNOLOGY (2022)

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Article Immunology

Differential Microbial Signature Associated With Benign Prostatic Hyperplasia and Prostate Cancer

Purandar Sarkar et al.

Summary: Chronic inflammation is associated with the onset of Prostate Cancer (PCa), and pathogen infection and tissue microbiome dysbiosis play a major role in both inflammatory response and cancer development. This study identified a potential microbiome signature associated with PCa and found significant correlations between human tumor viruses and PCa development.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Article Biochemistry & Molecular Biology

The Non Catalytic Protein ERG28 has a Functional Role in Cholesterol Synthesis and is Coregulated Transcriptionally

Isabelle M. Capell-Hattam et al.

Summary: In this study, researchers identified the noncatalytic protein ERG28 as a player in mammalian cholesterol synthesis. They found that ERG28 is transcriptionally regulated by the transcription factor SREBP-2 and interacts with enzymes involved in cholesterol synthesis. Knockout of ERG28 resulted in reduced cholesterol levels and impaired cholesterol synthesis. Additionally, ERG28 knockout also affected the activation of SREBP-2 under sterol-replete conditions. These findings highlight the importance of ERG28 in cholesterol synthesis and suggest that further understanding of this protein could contribute to therapeutic strategies for diseases associated with aberrant cholesterol metabolism.

JOURNAL OF LIPID RESEARCH (2022)

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Article Urology & Nephrology

Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia: AUA GUIDELINE PART IdInitial Work-up and Medical Management

Lori B. Lerner et al.

Summary: This article presents guidelines for effective management of male LUTS/BPH. By searching for the latest English language research studies and providing various levels of evidence to support different recommendations, a total of 19 guideline statements related to evaluation, work-up, and medical management were developed.

JOURNAL OF UROLOGY (2021)

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Article Oncology

KEYNOTE-921: Phase III study of pembrolizumab plus docetaxel for metastatic castration-resistant prostate cancer

Daniel P. Petrylak et al.

Summary: Pembrolizumab has shown activity in mCRPC patients as monotherapy and in combination with docetaxel and prednisone/prednisolone. The Phase III KEYNOTE-921 study aims to evaluate the efficacy and safety of pembrolizumab plus docetaxel in mCRPC patients previously treated with an NHA therapy, addressing the unmet need for treatment options in this patient population.

FUTURE ONCOLOGY (2021)

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Review Urology & Nephrology