4.7 Article

Computational screen to identify potential targets for immunotherapeutic identification and removal of senescence cells

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

Robert C. Jones et al.

Summary: The molecular characterization of cell types using single-cell transcriptome sequencing has led to a revolution in cell biology and provided new insights into the physiology of human organs. In this study, a human reference atlas was created, consisting of nearly 500,000 cells from 24 different tissues and organs, allowing for the molecular characterization of over 400 cell types, their tissue distribution, and tissue-specific variation in gene expression. By using multiple tissues from the same donor, the clonal distribution of T cells, tissue-specific mutation rate in B cells, and the analysis of cell cycle state and proliferative potential of shared cell types across tissues were identified. Additionally, cell type-specific RNA splicing was discovered and analyzed within an individual.

SCIENCE (2022)

Article Multidisciplinary Sciences

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

Dominik Saul et al.

Summary: The authors present and validate a senescence gene set called SenMayo, which can accurately identify senescent cells across different tissues and species. Using this gene set, senescent cells can be characterized at the single cell level and key intercellular signaling pathways can be identified.

NATURE COMMUNICATIONS (2022)

Article Dermatology

Senescent cell removal via JAG1-NOTCH1 signalling in the epidermis

Hisashi Yoshioka et al.

Summary: Research indicates that Notch signaling may be involved in the removal of senescent cells in the epidermis, while the age-related decrease in JAG1 expression in the basal layer may lead to the accumulation of senescent cells.

EXPERIMENTAL DERMATOLOGY (2021)

Article Biochemistry & Molecular Biology

A Quantitative Proteome Map of the Human Body

Lihua Jiang et al.

Article Cell Biology

Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements

Claudia Baumann et al.

JOURNAL OF CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence

Payel Sen et al.

MOLECULAR CELL (2019)

Article Multidisciplinary Sciences

L1 drives IFN in senescent cells and promotes age-associated inflammation

Marco De Cecco et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Transcriptome signature of cellular senescence

Gabriel Casella et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biochemistry & Molecular Biology

Human Ageing Genomic Resources: new and updated databases

Robi Tacutu et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

Senolytics improve physical function and increase lifespan in old age

Ming Xu et al.

NATURE MEDICINE (2018)

Article Multidisciplinary Sciences

Massive mining of publicly available RNA-seq data from human and mouse

Alexander Lachmann et al.

NATURE COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)

Jacqueline MacArthur et al.

NUCLEIC ACIDS RESEARCH (2017)

Editorial Material Multidisciplinary Sciences

The Human Cell Atlas: from vision to reality

Orit Rozenblatt-Rosen et al.

NATURE (2017)

Article Multidisciplinary Sciences

Cellular senescence mediates fibrotic pulmonary disease

Marissa J. Schafer et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

Maxim V. Kuleshov et al.

NUCLEIC ACIDS RESEARCH (2016)

Review Biochemistry & Molecular Biology

Cellular senescence in aging and age-related disease: from mechanisms to therapy

Bennett G. Childs et al.

NATURE MEDICINE (2015)

Article Multidisciplinary Sciences

Tissue-based map of the human proteome

Mathias Uhlen et al.

SCIENCE (2015)

Article Biotechnology & Applied Microbiology

Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts

Shiva Marthandan et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Biochemistry & Molecular Biology

The Digital Ageing Atlas: integrating the diversity of age-related changes into a unified resource

Thomas Craig et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Multidisciplinary Sciences

A draft map of the human proteome

Min-Sik Kim et al.

NATURE (2014)

Review Multidisciplinary Sciences

The role of senescent cells in ageing

Jan M. van Deursen

NATURE (2014)

Article Mathematical & Computational Biology

COMPARTMENTS: unification and visualization of protein subcellular localization evidence

Janos X. Binder et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2014)

Editorial Material Genetics & Heredity

The Genotype-Tissue Expression (GTEx) project

John Lonsdale et al.

NATURE GENETICS (2013)

Article Multidisciplinary Sciences

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Darren J. Baker et al.

NATURE (2011)

Article Cell Biology

DNA damage response and cellular senescence in tissues of aging mice

Chunfang Wang et al.

AGING CELL (2009)

Article Medicine, Research & Experimental

The mammalian phenotype ontology: enabling robust annotation and comparative analysis

Cynthia L. Smith et al.

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2009)

Review Cell Biology

Cellular senescence: when bad things happen to good cells

Judith Campisi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)